Serum vascular endothelial growth factor (VEGF) as tumor marker in human cancer
Journal Title: IP International Journal of Ocular Oncology and Oculoplasty - Year 2017, Vol 3, Issue 1
Abstract
Angiogenesis i.e. sprouting of new blood vessels play a critical role in the initial development of cancer as well as in tumor growth, progression and metastasis. It has been reported that increased intratumoral microvessel density correlated with high incidence of metastasis and poor prognosis. (1,2) The disruption of tumor angiogenesis may disrupt the tumor growth. (3) Angiogenesis depends on balance between positive and negative angiogenic factors released by the tumor cells. Tumor cells secrete a variety of stimulating factors like fibroblast growth factor, transforming growth factor, platelet derived endothelial growth factor and hepatocyte growth factor. These Biomarkers are used to assess angiogenesis.
Authors and Affiliations
Rajendra P Maurya
Keywords
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- EP ID EP293863
- DOI 10.18231/2455-8478 .2017.0001
- Views 63
- Downloads 0
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