Severe hypercholesterolemia mediated by lipoprotein X in a patient with cholestasis
Journal Title: Annals of Hepatology - Year 2015, Vol 14, Issue 6
Abstract
Lipoprotein X (LpX) is an abnormal lipoprotein associated with cholestasis. It is a significant cause of severe hypercholesterolemia and should always be considered in patients with cholestatic liver disease. This case highlights the significance of LpX as a cause of severe hypercholesterolemia in a patient with cholestasis secondary to a granulomatous hepatitis attributed to tuberculosis. Lipoprotein agarose gel electrophoresis and gradient gel electrophoresis were performed for the detection of LpX. The liver function tests, electrolytes, lipid profile and bile acids were also determined. Anti-tuberculous therapy was initiated and the liver functions improved with normalisation of the lipid profile.
Authors and Affiliations
Dineo Phatlhane, Annalise Zemlin
Keywords
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- EP ID EP78524
- DOI 10.5604/16652681.1171785
- Views 133
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