Shaping Up Mitochondrion in Motion
Journal Title: Dermatology – Open Journal - Year 2016, Vol 1, Issue 2
Abstract
We previously reported that hair follicle dermal papilla cells (HFDPCs) show two types of mitochondria, which are filamentous (untangled) and rounded (tangled) mitochondria. Platelet derived growth factor-AA (PDGF-AA) shifts the population balance toward the filamentous type that produces more adenosine triphosphate (ATP) than the other. In addition, the cells show filamentous mitochondria during the process of cellular migration. Furthermore, here we demonstrated that an inner membrane protein, optic atrophy 1 (OPA1), is involved in the filamentous-rounded transition of the organelle. We suggest that OPA1 confers longitudinal rigidity on the filamentous mitochondria. Other cells such as breast cancer cells utilize small fragmented mitochondria, instead of a filamentous form, in the migration process. Regarding the apparent inconsistency with those other reports on the morphological change upon the onset of cellular migration, we discuss communal feature of the regulation of mitochondrial morphology in different cellular systems: all previous reports showed that the organelle become slender or smaller in the energy-demanding activity.
Authors and Affiliations
Kuniyoshi Kaseda
Keywords
Related Articles
- EP ID EP550666
- DOI 10.17140/DRMTOJ-1-111
- Views 131
- Downloads 0
Microneedling: An Update
Aesthetic treatments are on the rise and according to the American Society of Plastic Surgery (ASPS), minimally invasive procedures comprise of approximately 89% of all cosmetic treatments. Microneedling is one of the ne...
Emerging Age of Opportunity for More Effective Treatments in Atopic Dermatitis
Atopic dermatitis (AD) is a chronic inflammatory disease characterized by widespread lesions, which manifest as erythematous areas with crusting and/or scaling, oozing, excoriations, and lichenification. Additionally, pr...
Tinea Incognito: Case Report
Tinea incognito (TI) is defined as absence of the classic annular configuration of tinea infection. It is caused by misuse of topical or systemic corticosteroids and less frequently by calcineurin inhibitors. Herein we p...
Fas Receptor: An Overview
The FAS receptor (FasR), also known as apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily 6 (TNFRSF6) is a protein that in humans is encoded by the FAS...
Acquired Melanocytic Nevus: An Unusual Case Presentation
Acquired Melanocytic Nevi (AMV) are common benign pigmented skin lesions. There arethree types which include junctional nevus, compound nevus and Intradermal Melanocytic Nevus (IMN). IMN are characterized clinically by d...