Shrinkage in Nonlinear Mixed-Effects Population Models: Quantification, Influencing Factors, and Impact

Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 4

Abstract

The online version of this article (doi:10.1208/s12248-012-9407-9) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Xu Steven Xu, Min Yuan, Mats O. Karlsson, Adrian Dunne, Partha Nandy, An Vermeulen

Keywords

Related Articles

Prodrug Applications for Targeted Cancer Therapy

Prodrugs are widely used in the targeted delivery of cytotoxic compounds to cancer cells. To date, targeted prodrugs for cancer therapy have achieved great diversity in terms of target selection, activation chemistry, as...

Novel system to investigate the effects of inhaled volume and rates of rise in simulated inspiratory air flow on fine particle output from a dry powder inhaler

This study evaluated the effect of inhaled volume and simulated inspiratory flow rate ramps on fine particle output from dry powder inhalers (DPIs). A simple, robust system was developed to account for “rate of r...

Workshop Report and Follow-Up—AAPS Workshop on Current Topics in GLP Bioanalysis: Assay Reproducibility for Incurred Samples—Implications of Crystal City Recommendations

The Conference Report of the 3rd AAPS/FDA Bioanalytical Workshop (Crystal City III) endorsed the concept that assay methods supporting bioanalytical data in submissions must demonstrate assay reproducibility by using inc...

A novel method for the determination of biliary clearance in humans

Biliary excretion is an important route of elimination and the biliary tract is a potential site of toxicity for many drugs and xenobiotics. Quantification of biliary excretion in healthy human volunteers is logistically...

Assuring quality and performance of sustained and controlled release parenterals: Workshop report

This is a summary report of the American Association of Pharmaceutical Scientists, the Food and Drug Administration and the United States Pharmacopoeia cosponsored workshop on “Assuring Quality and Performance of...

Download PDF file
  • EP ID EP681265
  • DOI  10.1208/s12248-012-9407-9
  • Views 72
  • Downloads 0

How To Cite

Xu Steven Xu, Min Yuan, Mats O. Karlsson, Adrian Dunne, Partha Nandy, An Vermeulen (2012). Shrinkage in Nonlinear Mixed-Effects Population Models: Quantification, Influencing Factors, and Impact. The AAPS Journal, 14(4), -. https://europub.co.uk./articles/-A-681265