Sialic acid (NANA) levels in women with and without previous gestation
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 1
Abstract
Background: Sialic acids are a family of nine-carbon acidic monosaccharides that occur naturally at the end of sugar chains attached to the surfaces of cells and soluble proteins. Serum Sialic acid has recently gained interest as a possible cardiovascular risk factor as well as a potential tumor marker. The effect of pregnancy/pregnancies on serum Sialic acid is unclear, particularly in the post-partum period. Aim: To study the level of sialic acid levels in women with and without previous gestation. Materials and Methods: Serum sample was taken between 37 and 42 weeks of gestation; in 20 primigravida women this was followed by a second serum sample at 12 weeks postpartum. Serum sample was collected and assayed for levels of sialic acid in 20 pregnant women who were gestational for the second time followed by a second sample at 12 weeks postpartum. Serum sialic acid concentration was also measured in non-pregnant age matched controls. Result: Serum sialic acid was significantly higher in primigravida group (n = 20): 70.7 +/- 8.9 mg/dl when compared to expectant mothers who were gestational more than once (n=20) group: 64.5 +/- 5.3 mg/dl. Serum sialic acid values were also higher in the post-partum group (n = 40): 67.4 +/- 4.6 mg/dl when compared to control group (n = 20). Conclusion: The elevated level of serum sialic acid in primigravida and subsequent pregnancies establishes that sialic acid is indeed elevated in pregnancy. The possible role/various roles of elevated sialic acid in pregnancy need extensive research targeting specifically metabolic syndrome.
Authors and Affiliations
K Piruthivirajan
Keywords
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