Sialometry and sialochemistry - A diagnostic tool in Sjogren’s syndrome.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Aim & Objective: The aim of the study is to assess the role of sialometry and sialochemistry as a diagnostic tool in Sjogren’s syndrome by quantifying the levels of sodium, potassium, chloride, urea, calcium, phosphate, total protein, creatinine, albumin and estimating the flow rate of whole unstimulated saliva in patients with a positive diagnosis of Sjogren’s syndrome in comparison with control group and thus utilizing the changes in the chemical levels in the diagnosis of Sjogren’s syndrome . Materials & Methods: A cross sectional study was done with 60 subjects divided into two groups, 30 in study group with mean age of thirty six years and 30 in control group with the mean age of forty three years. 9 among the study group had Primary Sjogren’s syndrome and 21 had Secondary Sjogren’s syndrome. Minor salivary gland biopsy was done to confirm the diagnosis of Sjogren’s. Unstimulated whole saliva was collected and the chemical analysis was done using diagnostic kits to estimate sodium, potassium, chloride, total protein, albumin, creatinine, urea, calcium and phosphate.The changes in the levels were statistically analysed. Results: Individuals with Sjogren’s syndrome showed very high significant reduction (P=0.001) in the salivary flow rate (0.18ml/min) and salivary phosphate (6.49mg/ml) level. There was very high significant increase (P=0.001) in the levels of salivary Na+(131.40mmol/min), Cl-(132.09mmol/min),albumin(6.18mg/dl) and creatinine(0.60mg/dl). Levels of total protein(278.17)showed a significant increase(P=0.05). There was no significant change in the levels of potassium(9.37 mmol/l), calcium (5.05mg/dl) and urea(9.83mg/dl). Conclusion: This study has established that the sodium, chloride, phosphate level of saliva could be used to diagnose Sjogren’s syndrome and to assess the prognosis of the disease. Clinical Significance: To utilize sialometry and sialochemistry as non invasive and cost effective diagnostic tools in Sjogren’s syndrome
Authors and Affiliations
Dr. Bakyalakshmi K, Dr. Jayachandran S, Dr. Ponranjini Vedeswari C
Keywords
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