SIGNIFICANCE OF FAST DISSOLVING ORAL FILMS AND ITS NOVEL APPROACH TOWARDS DRUG DELIVERY–A REVIEW
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 6
Abstract
Novel drug delivery system is one of the frontier areas of research towards achieving an innovative technique for drug administration which can improve drug safety, therapeutic efficacy, stability and selflife of an active drug. Over the past few decades, it is chosen as an important area of research to develop innovative methods for the health sector and pharmaceutical industries. Fast dissolving oral films (FDOFs) in the year of 1970 initiated as an alternative to the existing drug delivery system such as tablet, capsule, parenteral, syrup, emulsion, cream and ointment. FDOFs are one of the most popular drug delivery system due to its flexibility and comfort of use. These films have a potential to absorb the drug through oral buccal mucosa and directly enter to the systemic circulation by fast-pass metabolism. These films have a potential to provide better drug utilization by delivering systemically through intra-gastric and sublingual. These films are gaining popularity due to rapid drug absorption and immediate onset of action within a few minutes of administration in buccal cavity. FDOFs are very convenient to pediatric, geriatric and bedridden patient who faces difficulty in swallow. FDOFs can be used for the treatment of common cold, mouth ulcer, cardiac problem, sore throat and allergic conditions etc. These films can be formulated by simple methods using several ingredients such as polymers, active medicaments, stabilizing agent, surfactants, sweetening agent, flavoring agent coloring agent and saliva stimulating agent. Evaluation of FDOFs can be done by checking several parameters such as thickness, folding endurance, tensile strength, percentage of elongation anddisintegration test. Additionally, drug content and dissolution test are carried out to determine amount of active drug present in the film. This review article shows all the details about formulation evaluation, packaging and marketed available product.
Authors and Affiliations
Dr. S. K. Ershadul Haque
Keywords
Related Articles
- EP ID EP617697
- DOI -
- Views 207
- Downloads 0
ADVANCES IN GCF BIOMARKERS AS A DIAGNOSTIC AID IN PERIODONTITIS
Periodontitis is an inflammatory disease resulting in the loss of supporting structures of teeth. clinical attachment level, probing depth and radiographic findings form the basis of periodontal diagnosis and treatment p...
ASSESSMENT OF AWARENESS AND PREVALENCE OF ORAL CONTRACEPTIVE PILLS SIDE EFFECT AMONG SAUDI FEMALE SOCIETY: A CROSS SECTIONAL STUDY
Introduction: Oral contraceptive pills (OCPs) is the most commonly prescribed form of contraception in the US, and is highly effective when used perfectly.[1] OCPs contain combinations of female hormones estrogen and pro...
INFLUENCE OF THE SUGAR EXTRACTION METHOD OF COCONUT WATER ON THE CALCIUM, IRON, ZINC AND PHOSPHORUS CONTENTS
Sugars from immature coconut water were analyzed. All types sugars of coconut water showed high content Ca, Fe, Zn and P. The Ca and P content were highest in brown sugar than syrup and white sugar. Iron and zinc content...
DEPLETION OF OXYTETRACYCLINE FROM CHICKEN TISSUES
Oxytetracycline residue was evaluated in broiler tissues after oral administration of the drug in drinking water. Thirty broiler chickens-4 weeks old age were administered Oxytetracycline in drinking water for five conse...
OXIDANT, ANTIOXIDANTS AND SOME BIOCHEMICAL PARAMETERS IN PATIENTS WITH TYPE 2 DIABETIC NEPHROPATHY
This work was conducted to study the role of oxidative stress and some biochemical parameters in type 2 diabetic nephropathy patients. Fifteen type 2 diabetic nephropathy and ten type 2 diabetic patients (at the age 57-6...