Significance of genetic polymorphism of CYP2D6 in the pathogenesis of systemic sclerosis.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 2
Abstract
Background: Systemic sclerosis (SSc) belongs to the group of systemic diseases of the connective tissue, which are characterized by a chronic autoimmune inflammatory process. The studies on etiopathogenesis of autoimmune diseases focus on the impact the genetically conditioned impairment of xenobiotic metabolism may exert. The genetically polymorphic CYP2D6 is one of the most important phase I drug metabolizing enzymes. The knowledge of oxidation polymorphism in the course of SSc may be helpful in choosing more efficient and safer therapy, particularly in the case of a disease involving various organs and treated with drugs belonging to diverse therapeutic groups. The aim of the study was to evaluate the CYP2D6 polymorphism in the SSc patients and to investigate a possible correlation with disease susceptibility. Methods: The study was carried out in 77 patients with SSc and 129 healthy volunteers. The CYP2D6 genotypes were analyzed by polymerase chain reaction fragment length polymorphism (PCR-RFLP) method. Results: Risk of SSc development for particular genotype carriers expressed by the odds ratio (OR) was statistically significantly higher for subjects with CYP2D6*1/CYP2D6*4 (OR = 3.2; p = 0.001). A statistically significant correlation between the CYP2D6*4 allele prevalence and the risk for developing SSc was found (OR = 1.6; p = 0.029). Conclusions: The obtained results may suggest the influence of CYP2D6*4 gene mutated alleles on increased incidence of systemic sclerosis.
Authors and Affiliations
Małgorzata Barańska, Bożena Dziankowska-Bartkowiak, Elżbieta Waszczykowska, Mariola Rychlik-Sych, Jadwiga Skrętkowicz
Keywords
Related Articles
- EP ID EP97946
- DOI -
- Views 90
- Downloads 0
Neurochemical modulation of stress-induced cognitive inflexibility in a rat model of an attentional set-shifting task.
It is widely accepted that chronic stress, which is considered a risk factor for several neuropsychiatric disorders, may have detrimental effects on prefrontal functions. In animal models, chronic stress produces morphol...
AM251, cannabinoids receptors ligand, improves recognition memory in rats.
High density of cannabinoid receptors type 1 (CB1) in the brain suggests that endocannabinoid system plays an important role in the functioning of the central nervous system. Natural and synthetic cannabinoids are known...
Impact of maternal separation on neural cell adhesion molecules expression in dopaminergic brain regions of juvenile, adolescent and adult rats.
Stressful experiences in the early stages of life can influence brain development and maturation, and they can also increase the risk for some psychiatric disorders; however, the specific mechanisms of this effect are st...
Amphetamine-induced effects on neuropeptide Y in the rat brain.
Repeated (+)-amphetamine sulfate (AMPH) administration (5 mg/kg sc twicedaily for 6 days and once on day 7) markedly and reversibly decreased (until 96 h after the final dose)neuropeptide Y-like immunoreactivity (NPY-LI)...
Effects of standard heparin and low-molecular-weight heparins on the formation of murine osteoclasts in vitro.
Long-term administration of heparin can lead to development of osteoporosis. The aim of the present study was to examine the effects of standard heparin and low-molecular-weight heparins (nadroparin, enoxaparin, parnapar...