Significance of Pretreatment Testosterone Levels in Prostate Cancer Risk Groups
Journal Title: Üroonkoloji Bülteni - Year 2016, Vol 15, Issue 3
Abstract
Objective: In this report, patients, who had testosterone (TE) level data before prostate needle biopsy and who later underwent radical prostatectomy (RP) due to prostate adenocarcinoma, were evaluated. The TE levels were analyzed in patients divided into three groups according to the D’Amico risk classification. Materials and Methods: Patients in the low-risk group constituted group 1, those in the intermediate-risk group-group 2 and subjects of the high-risk group were in group 3. Prostate specific antigen and TE levels, biopsy and RP pathological findings and biochemical recurrence rates were evaluated. Then all data were compared between the groups. Results: We evaluated 81 patients, whose data on TE level were available. Twenty eight patients were included in Group 1, 45 were in Group 2 and 8 were in Group 3. The mean follow-up time was 37.7 months. Total testosterone (GTE) levels were detected to be lower in Group 3 (p=0.033) than in patients of Group 1 and Group 2. However, pathological stage (p=0.004), Gleason score (p<0.001), tertiary Gleason pattern (p=0.032), tumor volume (p<0.001), surgical margins positivity (p=0.023), lymph node positivity (p=0.01) and biochemical recurrence (p=0.026) rates were found to be higher in Group 3. Conclusion: In conclusion, preoperative low TTE levels in patients who underwent RP were found to be associated with high-risk disease according to the D’Amico risk classification.
Authors and Affiliations
Serdar Çelik, Ozan Bozkurt, Hüseyin Alperen Yıldız, Ömer Demir, Burçin Tuna, Kutsal Yörükoğlu, Güven Aslan
Keywords
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- EP ID EP228294
- DOI 10.4274/uob.699
- Views 120
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