SIGNIFICANCE OF SPOT URINE PROTEIN CREATININE RATIO VERSUS 24-HOUR URINE PROTEIN ANALYSIS AND THEIR CORRELATION IN QUANTIFICATION OF PROTEINURIA IN HYPERTENSIVE PREGNANT WOMEN- A PROSPECTIVE OBSERVATIONAL STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 13
Abstract
BACKGROUND We wanted to evaluate the efficacy of protein creatinine ratio in quantification of proteinuria in hypertensive pregnant women between 20 to 40 weeks to study the correlation between protein creatinine ratio of spot urine sample and the protein content of 24 hours urine collection. MATERIALS AND METHODS Hypertensive pregnant women between 20 to 40 weeks were included in the study. Protein/creatinine ratio was obtained from urine samples collected soon after 24-hours urine collection. Sensitivity and specificity, positive and negative predictive values of the protein/creatinine ratio for significant proteinuria (≥ 300 mg) were calculated, based on 24-hours urine total protein. RESULTS There was a strong correlation between the spot P/C ratio and 24-hour urine protein excretion (r = 0.715; P < .0001). The optimal spot P/C ratio cut-off point was 0.35 for 300 mg/24 h of protein excretion (preeclampsia), with a sensitivity, specificity, positive predictive value, and negative predictive value and accuracy of 91.8%, 93.33%, 98.73%, 66.66% and 92% respectively. CONCLUSIONS A significant correlation between the spot urine P/C ratio and 24-hour urine protein excr
Authors and Affiliations
Rekha Reddy, Sireesha Sireesha, Manjula Manjula, Shruthi Manvikar
Keywords
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- EP ID EP615897
- DOI 10.18410/jebmh/2019/227
- Views 79
- Downloads 0
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