SILVER NANOPARTICLES FUNCTIONALIZED GEL: PHYSICO-CHEMICAL PROPERTIES AND ANTIBACTERIAL ACTIVITY AGAINST ESCHERICHIA COLI, PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 2
Abstract
This study was performed to verify the stability, physicochemical properties and antibacterial activity of a carbomer based gel functionalized with silver nanoparticles (AgNPs) obtained by green synthesis. Three formulations of Gel-AgNP were done: 0.5, 1.0 and 2.0% of AgNPs. The gel is skin-compatible and had shown interesting rheological properties, assuming a pseudoplastic profile. In addition, the stability of the gel was obtained and it was extremely satisfactory for six months. The antibacterial activity was performed against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, showing satisfactory results for 1.0 and 2.0% AgNPs gels trough well-diffusion technique. The AgNPs gel could provide an alternative to conventional antibacterial formulations (topical use) for veterinary or human applications.
Authors and Affiliations
Pierre Basílio Almeida Fechine
Keywords
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