Similar Outcomes for Two Anemia Treatment Strategies among Elderly Hemodialysis Patients with Diabetes
Journal Title: Journal of Endocrinology and Diabetes - Year 2015, Vol 2, Issue 2
Abstract
Background/Aims: To compare mortality and cardiovascular risk in elderly dialysis patients with diabetes under two clinical strategies of anemia correction: maintaining hematocrit (Hct) between 34.5 and < 39.0% (high Hct strategy), and between 30.0 and <34.5% (low Hct strategy) using intravenous alpha epoetin. Methods: Observational data were used to emulate a randomized trial in which diabetic patients who initiated hemodialysis in 2006- 2008 were assigned to each anemia correction strategy. Inverseprobability weighting was used to adjust for measured timedependent confounding. Results: Comparing high with low hematocrit strategy, the hazard ratio (95% confidence interval) was 1.07 (0.83, 1.38) for allcause mortality and 1.00 (0.81, 1.24) for a composite mortality and cardiovascular endpoint. Conclusions: Among a cohort of elderly hemodialysis patients with diabetes, no differences were found between the low and high hematocrit strategies. A lower target hematocrit - per current Food and Drug Administration (FDA) guidelines - appears to be as safe as higher targets among this population.
Authors and Affiliations
Dennis Cotter, Thamer M, Zhang Y, Kaufman J, Hernán n
Keywords
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- EP ID EP333061
- DOI 10.15226/2374-6890/1/2/00111
- Views 118
- Downloads 0
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