SIMULTANEOUS ESTIMATION OF FAMOTIDINE AND RABEPRAZOLE SODIUM: METHOD DEVELOPMENT AND VALIDATION BY UV-SPECTROPHOTOMETRIC METHOD
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objectives: Study aimed for the simultaneous estimation of Famotidine and Rabeprazole sodium at 263 nm, λmax of Famotidine and 284 nm, λmax of Rabeprazole sodium.Methods: Method development and validation were done by UV spectrophotometric method.Results: The method developed obeyed Beer-Lambert’s law in the concentration range of 5-30 g/ml for both famotidine and rabeprazole. The results of the analysis have been successfully validated statistically. The %RSD confirms the precision of the proposed method and Recovery studies show the accuracy of the method.Conclusion: This method was simple, precise and accurate and was successfully applied to the determination of these drugs in the laboratory mixture.Â
Authors and Affiliations
Lenson Paul Dsouza, Marina Koland
Keywords
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