SIMULTANEOUS ESTIMATION OF GLIMEPIRIDE, PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE BY DERIVATIVE SPECTROPHOTOMETRY METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
The simple and accurate method of analysis to determine Glimepride (GLM), Pioglitazone hydrochloride (PIO) and Metformin hydrochloride (MET) in combined dosage forms was developed using second-derivative spectrophotometry and. GLM, PIO and MET in combined preparations (tablets) were quantified using the second-derivative responses at 233.4 nm for GLM, 265.4 nm for PIO and 252.6 nm for MET in spectra of their solutions in methanol. The calibration curves were linear [correlation coefficient (r) = 0.9990 for GLM, 0.9990 for PIO and 0.9990 for MET] in the concentration range of 5-25 μg/ml for GLM, 5–25 μg/ml for PIO and 2–12 μg/ml for MET. The method was validated and found to be accurate, precise, and specific. The method was successfully applied to the estimation of GLM, PIO and MET in combined tablet formulations.
Authors and Affiliations
Deepa Patel , Laxmanbhai Patel , Madhabhai Patel , Advaita Patel
Keywords
Related Articles
- EP ID EP86410
- DOI -
- Views 142
- Downloads 0
HEPATOPROTECTIVE EFFECT OF METHANOLIC EXTRACT OF HEDYOTIS HERBACEA LINN IN CCl4 TREATED MALE RATS
To evaluate the hepatoprotective effect of methanolic extract of Hedyotis herbacea Linn in rats treated with CCl4. In Hepatotoxic rats, liver damage was studied by assessing parameters such as aspartate amino transferase...
FORMULATION AND EVALUATION OF GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF STAVUDINE
The present study was designed to formulate and evaluate hydro dynamically balanced Floating Drug Delivery Systems as controlled release modules, which prolongs the release rate of the drugs. Stavudine is an anti- retrov...
FORMULATION AND EVALUATION OF BACLOFEN CONTROLLED POROSITY OSMOTIC PUMP TABLETS
In the present study, attempts were made to develop and evaluate the controlled porosity osmotic pump (CPOP) based drug delivery system of sparingly water soluble drug Baclofen. Formulation variables, such as, levels of...
DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR THE ESTIMATION OF ZILEUTON IN BULK AND IN PHARMACEUTICAL DOSAGE FORM BY UV SPECTROSCOPY
The aim of this work was to develop and validate a simple estimation method of Zileuton in bulk powder and tablet using UV spectrophotometric method. The method was developed using methanol as a solvent and absorbance wa...
STUDY ON EFFICACY OF DARANA KARMA IN ‘PAKVA VIDHRDHI’
Vidhrdhi or Pyogenic abscess is a common entity comes across in day to day life. It presents as a localized swelling with pain, reddish discoloration, local rise of temperature, tenderness and restricted function of the...