Simultaneous Spectrophotometric Estimation of Telmisartan and Amlodipine Besylate in Tablet Dosage Form
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2015, Vol 3, Issue 3
Abstract
A simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Telmisartan (TEL) and Amlodipine Besylate (AML) in combined tablet dosage forms. The method involves determination using the simultaneous equation method, the sampling wavelengths selected are ‘TLM’ = 297nm.and ‘AML’ =238nm., over the concentration ranges of 8-48μg/ml for ‘TEL’ and 1-6 μg/ml for ‘AML’ respectively. The method was validated for linearity, accuracy, precision, robustness and application for assay as per ICH guidelines. The proposed method is simple, economical, accurate and precise, and could be successfully employed in routine quality control for the simultaneous analysis of Telmisartan (TEL) and Amlodipine Besylate (AML).
Authors and Affiliations
Gupta NK| NIMS Institute of Pharmacy, NIMS University, Jaipur, 303121, Rajasthan, India, Peepliwal A| NIMS Institute of Pharmacy, NIMS University, Jaipur, 303121, Rajasthan, India, Rathore DS| NIMS Institute of Pharmacy, NIMS University, Jaipur, 303121, Rajasthan, India, Gupta P| MSJ Govt.PG College Bharatpur. 321001, Rajasthan, India
Keywords
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