Sodium fluoride induced antioxidant defense impairment and impaired renal biomarkers and the ameliorative role ofselenium and curcumin in male mice
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2014, Vol 4, Issue 0
Abstract
Objective: To evaluate the sodium fluoride (NaF) intoxicated kidney function parameters and also assess the ameliorating effects of selenium and curcumin extract. Methods: Mature male mice (weighing 35-45 g) were given intraperitoneally NaF (10.3 mg/kg) and/or selenium (0.5 mg/kg)+curcumin extract (60 mg/kg) daily for 4 weeks. Results: In our study, NaF exposure resulted in an increase in the urea, creatinine, triglycerides, total cholesterol, high density lipoprotein, low density lipoprotein and very low density lipoprotein levels with respect to the control. As a result, NaF induced antioxidant defense system impairment and renal impairment which was reduced by curcumin extract and/or selenium to great extent by the entire restoration of the histological structures. Conclusions: Our study showed that selenium and curcumin extract treatment alleviated NaF intoxication-induced oxidative damage of mice.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP230913
- DOI 10.1016/S2222-1808(14)60771-4
- Views 94
- Downloads 0
Knowledge and attitude of healthcare workers and patients on healthcare associated infections in a regional hospital in Ghana
Objective: To assess knowledge and attitude of healthcare workers (HCWs) and patients on healthcare associated infections (HAIs) in the central regional hospital in Ghana. Methods: The purposive random sampling method wa...
Prevalence and antibiogram profiles of Escherichia coli O157:H7 isolates recovered from three selected dairy farms in the Eastern Cape Province, South Africa
Objective: To investigate the occurrence and antibiotics susceptibility of Escherichia coli (E. coli) O157:H7 isolates from raw milk, cattle udder, milking machines and worker’s hand swabs from three selected commercial...
Repetitive sequence-based PCR fingerprinting and the relationship of antimicrobial-resistance characteristics and corresponding genes among Salmonella strains from pig production
Objective: To investigate the relationship between antimicrobial resistance characteristics and corresponding genes, and to diversify repetitive element sequence-based PCR (rep-PCR) fingerprinting of three Salmonella ser...
Evaluation of the anticancer potentials of Origanum marjorana on fibrosarcoma (HT-1080) cell line
Objective: To evaluate the potential anticancer activity of Origanum majorana (marjoram) (O. marjorana) on the fibrosarcoma cancer cell line HT-1080 through various in-vitro assays. Methods: Crude extracts were prepared...
Incidence of Dirofiaria immitis in dogs presented at University of Nigeria, Nsukka Veterinary Teaching Hospital using wet smear and buffy coat techniques
Objective: To determine the incidence of Dirofilaria immitis (D. immitis) in dogs using the wet mount and buffy coat techniques for rapid detection of microfilaria in blood samples collected from dogs, to compare the two...