SOLID LIPID NANOPARTICLES AND NANO LIPID CARRIERS: AS NOVEL SOLID LIPID BASED DRUG CARRIER
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 2
Abstract
Interest in lipid based drug delivery has developed over the past decade fuelled by a better understanding of the multiple roles lipids may play in enhancing oral bioavailability. Moreover, the emergence of novel excipients with acceptable regulatory and safety profiles coupled with advances in formulation technologies have greatly improved the potential for successful lipid based formulations. Solid lipid nanoparticles (SLN) introduced in 1991 represent an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. This paper reviews the present state of the art regarding production techniques for SLN/ nanostructured lipid carrier (NLC), drug incorporation method and types, stability. The potential of SLN/NLC to be exploited for the different administration routes is also highlighted.
Authors and Affiliations
Girish Singhal, Rakesh Patel, B. G. Prajapati, Nikunjana Patel
Keywords
Related Articles
- EP ID EP97709
- DOI -
- Views 131
- Downloads 0
PRECLINICAL EVALUTION OF ANTIUROLITHIATIC ACTIVITY OF SWERTIA CHIRATA STEMS
The aim of our present study is to evaluate preventive effect of swretia chirata drug in experimentally induced urolithiasis model in rat. Rats were induced to produce renal stone by providing them 0.75% v/v ethylene gly...
PHYTOCHEMICAL EVALUATION & ANTIMICROBIAL EFFICIENCY OF THREATENED MEDICINAL PLANT OF ANDHRA PRADESH PTEROSPERMUM XYLOCARPUM (THADA TREE)
Pterospermum. Xylocarpum (Family: Sterculiaceae) is a wild medicinal plant distributed throughout India and south East Asia. It is used against treatment of joint diseases like gout, rheumatism, arthritis. In present stu...
ANTIMICROBIAL ACTIVITY OF DIFFERENT THIOSEMICARBAZONE COMPOUNDS AGAINST MICROBIAL PATHOGENS
Thiosemicarbazone belongs to a large group of thiourea derivatives, whose biological activities are a function of parent aldehyde or ketone moiety. They have been evaluated over the last 50 year as antiviral, antibacteri...
ANTI-ALZHEIMER POTENTIAL OF ORANGE JUICE
Orange (Citrus sinensis) is well known for its nutritional and medicinal properties throughout the world. This study was undertaken to test the effect of orange juice on the memory of mice. A total of 228 mice divided in...
AYURVEDIC FORMULATIONS FOR THE MANAGEMENT OF EPILEPTIC DISORDERS
Epilepsy is a most common disorder in neuropsychiatric outpatient department. Most of the times it’s Diagnosis and treatment is difficult. Apasmara is a similar clinical condition described in all major classics of Ayurv...