SOLUBILITY ENHANCEMENT OF LERCANIDIPINE HYDROCHLORIDE BY COCRYSTALLISATION.
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 3
Abstract
In this study, the significant effect of malonic acid on enhancement of solubility of lercanidipine hydrochloride by simple solvent change process has been demonstrated. Malonic acid and lercanidipine hydrochloride were simultaneously crystallised using water as anti-solvent. The pure drug and different concentrations of malonic acid were characterized in terms of solubility, percentage yield, melting point, crystallinity, thermal behaviour, compatibility studies and surface morphology. The optimised cocrystal formulation exhibited enhancement in aqueous solubility.
Authors and Affiliations
Asija Rajesh*| Professor & Principal, Maharishi Arvind Institute of Pharmacy, Mansarover, Jaipur, Rajasthan, India-302020., Mangukia Dhruv| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Asija Sangeeta| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Patel Jaimin| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Patel Chirag J| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020, Patel Pinkesh| Department of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India-302020
Keywords
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