Soluble Cytokine Receptor Subunits Modulate Catecholaminergic Cell Activity
Journal Title: International Neuropsychiatric Disease Journal - Year 2014, Vol 2, Issue 3
Abstract
Soluble cytokine receptors (SCR) modulate cytokine signaling and are increased in states of abnormal immune activation. SCR’s are also increased in psychiatric and neurological disorders associated with altered brain catecholaminergic activity; although, there is no evidence that any soluble cytokine receptor alone modulates such activity. One such soluble cytokine, soluble IL-2 receptor (sIL-2R) modulates lymphocyte activity. Here, we discovered that soluble IL-2 receptors (sIL-2Rα, sIL-2Rβ) dose-dependently increase cAMP levels in differentiated PC12 cells. sIL-2Rγ and sIL-6Rα have produced no effect. Co-treatment of sIL-2Rs with IL-2 alters cAMP levels in a concentration-dependent manner. This is the first evidence that soluble receptors modulate catecholaminergic cell activity. Thus, soluble cytokine receptors, including the α and β subunits, may represent new therapeutic targets for relevant psychiatric and neurological disorders.
Authors and Affiliations
Ankur Patel, Jagadeesh Batana, Ishdeep Narang, Steven S. Zalcman
Keywords
Related Articles
- EP ID EP241482
- DOI 10.9734/INDJ/2014/7231
- Views 148
- Downloads 0
Psychological Assessment and Five Years Follow up of a Client under Vocational Guidance: A Case Study
This case study was carried out to undertake a psychological assessment and follow up of an undecided client who needed vocational guidance and counseling to make an appropriate and correct career choice. The case study...
Alzheimer’s Disease Management: Current Therapy and Recent Drug Development
Alzheimer’s disease is an age-related central nervous disorder that has created daunting challenges for the treating physicians, the families and the society. Alzheimer’s disease, a leading neurodegenerative disorder wor...
Training Contributions of Executive Functions in Perception of Quality of Life in Elderly
Aims: Verify the presence or lack of improvement in quality of life perception, comparing the results of the evaluation from both elderly groups that participated on the executive functions training research. Study Desig...
Associated Factors of Stress among Faculty Members of Kathmandu Valley
Background: With mushrooming of health Science College in Kathmandu valley, the occupational related stresses were increasing among faculty members. The stress makes the great deals for the daily life. The objective of t...
Clinical Profile of Early Onset Psychosis in a Nigerian Sample
Aims: This study assesses the clinical profile of children and adolescents with psychotic disorders presenting to a psychiatric facility in Lagos, Nigeria. Study Design: The study design was a retrospective chart review...