SPECTROFLUORIMETRIC ESTIMATION OF EMPAGLIFLOZIN IN THE PRESENCE OF ITS OXIDATIVE DEGRADATION PRODUCT
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 7
Abstract
A Spectrofluorimetric method has been developed and validated for the selective quantitative determination of empagliflozin in the presence of its oxidative degradation product. In this method the fluorescence of empagliflozin in methanol at 305 nm was measured after excitation at 234 nm. The proposed method was validated according to ICH guidelines and show high sensitivity, accuracy and precision. Furthermore this method was successfully applied to the analysis of empagliflozin in pharmaceutical dosage form without interference from additives and the results were statistically compared to a reported method and found no significant difference.
Authors and Affiliations
Dr. Ahmed M. Abdelzaher
Keywords
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