SPECTROPHOTOMETRIC DETERMINATION OF RANITIDINE HYDROCHLORIDE (RNH) IN PHARMACEUTICAL FORMULATION USING 9-FLUORENYLMETHYL CHLOROFORMATE (FMOC-Cl)
Journal Title: Asian Journal Of Pharmaceutical Research and Development - Year 2018, Vol 6, Issue 6
Abstract
A new, simple and sensitive spectrophotometric methodis developed for the determination of ranitidine hydrochloride (RNH). The proposed method is based upon reaction of RNH with 9-fluorenylmethyl chloroformate (FMOC-Cl) in borate buffer of pH 8.0 producing an absorption maximum at 255 nm. All parameters required for the reaction conditions are investigated. Linearity is verified with a range of 2-16 μg/mL and is described by the regression equation y = 61129 x + 0.0354 with a correlation coefficient of 0.9998 (n = 7). The limit of detection (LOD) and the limit of quantification (LOQ) were calculated as per ICH guidelines and were found to be 0.2219 and 0.6724 μg/mL, respectively. The method was successfully applied for the determination of RNH in pharmaceutical formulation. Therefore, the method can be used for routine analysis of RNH in quality control laboratories
Authors and Affiliations
Shahd Moutasim Merghani, Ahmed Elbashir Abdalla
Keywords
Related Articles
- EP ID EP513628
- DOI 10.22270/ajprd.v6i6.454
- Views 134
- Downloads 0
ASSESSMENT OF MAJOR COMPLICATIONS IN PREGNANCY: A SINGLE CENTER STUDY
Pregnancy complications in our country are common in spite of a lot of progress made in antenatal care of pregnant women in the recent times. The complications range from simple anemia to ectopic pregnancy. We conducted...
A REVIEW ON: WOUND HEALING
Wound healing is a biological process that begins with trauma and ends with scar formation. There are two types of tissue injury: full and partial thickness. Partial thickness injury is limited to the epidermis and super...
ANTIBACTERIAL ACTIVITY OF AERIAL PARTS OF DIFFERENT SPECIES OF ZIZIPHUS GENUS
The leaves and stem powder alcoholic extracts of Ziziphus ziziphus and Ziziphus xyloporus were selected from Ziziphus genus are tested for their antibacterial potential against E. coli ATCC 8739, S. typhi ATCC 23564, S....
RESEALED ERYTHROCYTE DRUG DELIVERY SYSTEM
Erythrocytes, the most abundant cells in the human body, have potential carrier capabilities for the delivery of drugs. New drug delivery systems have been developed to overcome the limitations associated with the conven...
HAEMOPHILIA: AN OVERVIEW
Haemophilia also called hemophilia, is a mostly inherited, genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. This results in people bleeding longer after an injury,...