SPECTROPHOTOMETRIC SIMULTANEOUS ESTIMATION OFAMLODIPINE BESYLATE AND LISINOPRIL DIHYDRATE IN TABLET DOSAGE FORMS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 4
Abstract
Amlodipine Besylate and Lisinopril dihydrate are used for the treatment of hypertension. A binary mixture of Amlodipine Besylate (AML) and Lisinopril dihydrate (LSD) was determined by UV spectroscopic methods. The major aim of this research work is to develop simple, economical, accurate, and precise methods for simultaneous estimation of Amlodipine Besylate (AML) and Lisinopril dihydrate (LSD) in tablet dosage form. The method involved to solve simultaneous equations based on measurement of absorbance at two wavelengths 240nm (λmax of Amlodipine Besylate (AML)) and 218nm (λmax of Lisinopril dihydrate (LSD)). The two drugs followed Beers- Lamberts law over the concentration range of 2μg/ml-30μg/ml for AML and 2μg/ml -30μg/ml for LSD. The accuracy and precision of the methods were determined and the methods validated statically and this technique may be employed to analysed the drug containing Amlodipine besylate (AML) and Lisinopril dihydrate (LSD).
Authors and Affiliations
Manisha Masih*| PhD. Research Scholar, Department of Pharmaceutical Science-Jayoti Vidyapeeth Womens University, Vedant Gyan Valley, Jharna Mahala Jobner Link Road, NH-8, Jaipur Rajasthan-303122, India., Abhilasha Mittal| Jayoti Vidyapeeth Womens University, Vedant Gyan Valley, Jharna Mahala Jobner Link Road, NH-8, Jaipur Rajasthan-303122, India., B. C. Nandy| Jayoti Vidyapeeth Womens University, Vedant Gyan Valley, Jharna Mahala Jobner Link Road, NH-8, Jaipur Rajasthan-303122, India.
To Study the Mechanisms of Granule Formation in the Wet Granulation Process
Traditionally wet agglomeration processes have been considered an empirical art, with great difficulties in predicting and explaining observed behavior. Industry has faced a range of problems including poor product quali...
Preparation and Evaluation of Imiquimod Loaded Liposomal Dispersion: Part-I
The aim of present investigation was to encapsulate Imiquimod into liposomes and optimization of process and formulation variables, characterization of liposome with respect to shape, lamellarity, drug entrapment efficie...
BIOCHEMICAL ANALYSIS OF LEAVES OF SOME MEDICINAL PLANTS OF MARATHWADA REGION IN MAHARASHTRA
The seasonal variation of chlorophyll a, chlorophyll b and carotenoid have been investigated in leaves of Butea monosperma, Madhuca indica, Syzygium cumini and Mimusops elengi are important medicinal plants. Comparativ...
HELLP SYNDROME: A BRIEF REVIEW
HELLP is an abbreviation of hemolysis (H), elevated liver enzyme (EL), and low platelet count (LP) which is a serious complication in pregnancy and also described as a severe form of preeclampsia and which is also associ...
MicroRNAs in health and disease; a review of its multifaceted roles
A new class of noncoding small RNAs, called microRNAs (miRNAs), has emerged as important regulators in biological processes. The important role of miRNAs in inflammation and immune response is highlighted by studies in w...