Spectrum of Antimicrobial Sensitivity of Escherichia Coli in Sputum in a Tertiary Medical Centre in Kolkata, West Bengal, 7 Years’ Experience
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 10
Abstract
Introduction: E coli though is a normal inhabitant of human gastrointestinal tract but in case of immunocompromized patients it is responsible for producing different type of diseases involving different systems of the body. Due to irrational use of antibiotics this organism demonstrated progressively increasing resistance to different commonly used as well as highly selective antibiotics. Present study tried to demonstrate the spectrum of sensitivity to different antibiotics for E coli from the sputum of the patients. Material and methods: In this retrospective study sputum was isolated from the 1078 patients suffering from chest infections of K P C Medical College and Hospital, Jadavpur, and Kolkata and was sent to Microbiology department for culture and sensitivity. Results: Total number of E coli was 48 (4.46%). This organism was highly sensitive to carbapenem group of drugs (72.91%—85.41%), tigicycline (70.83%), polymixin B (68.75%) and colistin (64.58%) and chloramphenicol and amikacin (62.5%), netilmicin (60.41%). Amoxicillin (2.08%), oxacillin (0%), third and fourth generation cephalosporins (0% -- 27.08%), azithromycin (0%), erythromycin (2.08%) demonstrated highest resistance and aminoglycosides except amikacin and netilmicin showed moderate resistance to E coli. Conclusion: Due to injudicial use of broad spectrum antibiotics there is evidence of increasing resistance of these bacteria to very commonly used as well as highly selective antibiotics. One should do proper investigation prior to start the antibiotics. So it may be a resolution that only after getting proper sensitivity report we can use proper antibiotics. Periodic antimicrobial surveillance in case of hospital acquired infections is needed to update the guidelines on proper choice of organism specific as well as empiric antibiotics and only this can prevent the creeping of resistance to antibiotics to organism
Authors and Affiliations
Ashis Kumar Saha, Payodhi Dhar
Keywords
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