Spinal anesthesia with ropivacaine: A double-blind study on the efficacy and safety of 0.5% and 0.75% solutions in patients undergoing perineal and lower limb surgeries
Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 8
Abstract
Background: Ropivacaine, a long-acting amide local anaesthetic agent, is less lipophilic than bupivacaine. Intrathecally, it has been used for day care procedures as it provides adequate sensory block with early motor recovery. It has an improved safety profile over bupivacaine with a reduced central nervous system and cardio toxic potential. This double blind randomized study was conducted to compare efficacy and safety of two different concentrations of intrathecal ropivacaine in perineal and lower limb surgeries. Material And Methods: A total of 100 patients were randomly divided into two equal groups. Group I received 0.5% and Group II received 0.75% isobaric Ropivacaine. After spinal anesthesia, the patient’s pulse rate, systolic, diastolic and mean BP along with sensory and motor block were recorded at every three minutes. Sensory and motor blocks were assessed by pin prick test and Bromage scale respectively. Results: Heart rate, systolic and diastolic blood pressure in both the groups did not vary significantly. Cardiovascular changes were unremarkable throughout. We found that the 0.75% ropivacaine solution resulted in a higher frequency of complete motor block and a longer duration of motor block in the lower limbs than 0.5%. Conclusion: Intrathecal administration of 22.5mg of 0.75% isobaric Ropivacaine produced better quality and longer duration of analgesia, reliable quality of motor block, better postoperative outcome with minimum side effects as compared to 15mg of isobaric 0.5% ropivacaine in perineal and lower limb surgeries.
Authors and Affiliations
Harish K, Sunil K S
Keywords
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