Split-course chemoradiotherapy with S-1, a novel oral fluorouracil, and cisplatin for distant metastases of oesophageal cancer stage IVb
Journal Title: Journal of Cancer Research & Therapy - Year 2017, Vol 5, Issue 1
Abstract
Objectives: To evaluate the efficacy and safety of split-course chemoradiotherapy with S-1, a novel oral fluorouracil, together with cisplatin in patients with distant oesophageal cancer stage IVb metastasis. Methods: Forty-one patients with distant oesophageal cancer metastasis and performance status 0 or 1 received split-course chemoradiotherapy with S-1 and cisplatin. All 41 patients were reviewed retrospectively. Chemoradiotherapy comprised two courses of 30-Gy radiotherapy over three weeks plus daily oral S-1 (70mg/m2/day) for two weeks and a 24 h cisplatin infusion (70mg/m2) on Day 8, with a two week interval between the two courses. Results: The most frequent adverse events (AEs) were grade 3 and 4 neutropenia (29.2%), thrombocytopenia (9.8%), and anaemia (7.3%). Non-haematological AEs were generally mild. AEs in the initial course of chemoradiotherapy remitted during the second interval week. Overall, the complete response rate was 22.0% and endoscopic complete response rate for primary lesion was 65.9%. Thirty-one patients (75.6%) became asymptomatic and regained normal swallowing function. The overall median survival time was 12 months. Conclusion: This retrospective investigation showed that split-course chemoradiotherapy with S-1 and cisplatin had an encouraging safety profile together with good efficacy. Potentially, this regimen may become a standard for distant metastasis of oesophageal cancer stage IVb.
Authors and Affiliations
Hiroaki Iwase, Masaaki Shimada, Noboru Hirashima, Nobumitsu Ryuge, Momoko Goto, Takashi Kondo, Daiki Tanaka, Satoshi Unita, Eriko Kato
Keywords
Related Articles
- EP ID EP535755
- DOI 10.14312/2052-4994.2017-1
- Views 83
- Downloads 0
Evaluation of serum big endothelin-1 for the diagnosis and prediction of disease recurrence in breast cancer patients
Big endothelin-1 (big ET-1) is the biological precursor of endothelin-1 (ET-1) and it is known as an indicator for the degree of activation of endothelin system. Therefore, this study was designed to investigate the seru...
Diagnostic problems and immune contexture in a case of cecal medullary carcinoma
Medullary carcinoma (MC) of the colon has recently been described as a separate variant of colorectal carcinoma, associated with microsatellite instability. Despite its morphological similarities to poorly differentiated...
With increasing age at tumor diagnosis in familial cancer: Cancer is limited to fewer organs
Hereditary cancer that has monogenic inheritance affects every tenth patient, on average, who is diagnosed with cancer, and it has been suggested, based on twin studies, that approximately 30% of all cancer patients have...
Biomarker screening of oral cancer cell lines revealed sub-populations of CD133-, CD44-, CD24- and ALDH1- positive cancer stem cells
Head and neck squamous cell carcinoma (HNSCC) ranks sixth worldwide for cancer-related mortality. For the past several decades the mainstay of treatment for HNSCC has been surgery and external beam radiation, although mo...
Gastrointestinal stromal tumour: From the clinic to the molecules
GastroIntestional stromal tumours (GISTs), the most frequent sarcoma in the gastro-intestinal (GI) tract, are highly resistant to conventional chemotherapy and radiotherapy. These tumours have activating mutations in two...