SPLIT-HALF TABLETS: A COMPLETE REVIEW FOR ANALYTICAL TESTING
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 9
Abstract
A solid oral dosage form (as a tablet) which is an immediate or extended-release dosage form which necessitates the scoring bisect of the tablet. This review discusses the quality attributes and interpretations for the split studies of the various tablet formulations using the analytical techniques. Each method of analysis for the evaluation of split-half tablets in terms of its critical quality attributes discusses in detail explanation of analytical methodology and challenges in formulation development. The results for quantitative analytical evaluation in terms of finished product/stability testing and release of the split-half drug product against the acceptance criterion and also discusses the flowchart guidance for the investigation of out of specification results. The present article provides an insight into the complete analytical evaluation of split-half drug product testing according to the requirements of tablet scoring as per US food and drug administration.
Authors and Affiliations
LAKSHMI NARASIMHA RAO KATAKAM
Keywords
Related Articles
- EP ID EP646612
- DOI -
- Views 128
- Downloads 0
NON-NEOFORMANS CRYPTOCOCCEMIA IN A PATIENT WITH HODGKIN'S LYMPHOMA
Cryptococcemia attributed to non-neoformans cryptococci has not received much attention due to the relative scarcity of reported cases. The primary aim of this case report is to highlight several notable characteristics...
PRESCRIPTION WRITING PRACTICES AND ERRORS IN PRESCRIPTIONS CONTAINING CARDIOVASCULAR DRUGS ESPECIALLY ACE INHIBITORS IN KARACHI, PAKISTAN
ABSTRACTObjective: This is the first study related to the prescribing errors in cardiovascular prescription drugs especially Angiotensin converting enzymeinhibitors (ACEIs) conducted with the aim to identify the prescrib...
THE ROLE OF HEALTH INFORMATION SYSTEM IN MATERNAL AND CHILD HEALTHCARE SERVICES
Health information system deals with any system that helps in capturing, storing, transmitting, and managing health-related information of an individual or to demonstrate the activities or organizations working within he...
FORMULATION AND EVALUATION OF GEL LOADED WITH MICROSPHERES OF APREMILAST FOR TRANSDERMAL DELIVERY SYSTEM
Objective: The main objective of the present research work was to formulate and evaluate gel loaded with microspheres of apremilast to increase bioavailability and to reduce the dosing frequency and to improve patient co...
EVALUATION OF GENOTOXICITY PROFILE OF JASADA BHASMA (A ZINC-BASED MINERAL FORMULATION) IN SWISS ALBINO MICE
  Objective: Genotoxicity is regarded as one of the potential risk factors for causing pathological diseases. It was confirmed that many chemicals have the mutagenic activity which leads to cancer. A compound which int...