Spot Urine Albumin Creatinine Ratio- A Reliable And More Convenient Test For Diagnosis Of Nephrotic Syndrome In Children
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Aim and objective - Nephrotic syndrome is a nonspecific disorder in which the kidneys are damaged, causing them to leak large amounts of protein (proteinuria at least 3.5 grams per day per 1.73m2 body surface area) from the blood into the urine. It is common among 2 – 6 years old boys. To diagnose childhood nephrotic syndrome precise urine protein excretion has to be measured for which 24 hrs urine sample needs to be collected. But the procedure 24 hrs urine sample collection of a child becomes very tedious and cumbersome and the exact volume may not be correctly collected leading in inaccurate estimation of protein excretion. So in our study we have done a comparative analysis of 24 hr urine protein levels and spot urine albumin creatinine ratio in patients and normal healthy controls and evaluated the efficacy of both methods. Material and methods – Patients attending the department of pediatrics of HMCH were assessed and healthy age matched children were used as control. Urine protein was measured using dye based method, urine Creatinine was measured by Jaffe’s method and urine albumin was measured using immunoturbidemetric method. Result – 24 hrs urine protein values measured in patients with nephritic matched well with the urine albumin creatinine ratio. Conclusion – The result showed the spot urine albumin creatinine ratio is as accurate as 24 hrs urine protein estimation and can be used in pediatric age group for diagnostic parameter in nephrotic syndrome
Authors and Affiliations
Dr Brijesh Mukherjee, Dr Biswajeeta Saha
Keywords
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- EP ID EP381100
- DOI 10.9790/0853-1708065157.
- Views 56
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