STABILITY STUDIES OF RIBAVIRIN SYRUP
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5
Abstract
Ribavirin is an antiviral agent commonly used for the treatment of severe acute respiratory syndrome. The present study investigated the stability of marketed oral Ribavirin syrup. The syrup was subjected to accelerated stability testing at 40°C and 75% RH for 6 months as per ICH guidelines. HPLC method to estimate Ribavirin was developed and validated. Employing a validated high-performance liquid chromatographic method, the Ribavirin content of the syrup has been demonstrated to exhibit changes throughout the storage period. No physical changes was observed in syrup suggesting that it remained physically stable, but effected the chemically stability of syrup under the stated conditions.
Authors and Affiliations
Dhanyakumar Chougule, Nilofar Naikwade
Keywords
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- EP ID EP221881
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