Stem Cells in Neurodegenerative Disorders - A broad Overview
Journal Title: Journal of Regenerative Biology and Medicine - Year 2021, Vol 3, Issue 6
Abstract
Stem cell therapy is an approach to use cells that have the ability of self-renewal and to differentiate into different types of functional cells that are obtained from embryo and other postnatal sources to treat multiple disorders. These cells can be differentiated into different types of stem cells based on their specific characteristics to be totipotent, unipotent, multipotent or pluripotent. As potential therapy, pluripotent stem cells are considered to be the most interesting as they can be differentiated into different type of cells with similar characteristics as embryonic stem cells. Induced pluripotent stem cells (iPSCs) are adult cells that are reprogrammed genetically into stem cells from human fibroblasts through expressing genes and transcription factors at different time intervals. In this review, we will discuss the applications of stem cell therapy using iPSCs technology in treating neurodegenerative disorder such that Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS). We have also broadly highlighted the significance of pluripotent stem cells in stem cell therapy.
Authors and Affiliations
Fariha Khaliq1 and Maleeha Hassan2
Keywords
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- EP ID EP707393
- DOI https://doi.org/10.37191/Mapsci-2582-385X-3(6)-089
- Views 69
- Downloads 0
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