Strategies of Hyperglycemia Management among Patients with Diabetic Nephropathy, Renal Impairment, Hypertension and Lipid Disorders
Journal Title: Journal of Endocrinology and Diabetes - Year 2015, Vol 2, Issue 1
Abstract
Diabetic nephropathy, a microvascular complication, usually starts by the development of incipient nephropathy (microalbuminuria), then proteinuria, reduced glomerular filtration rate and finally renal impairment or Chronic Kidney Disease (CKD). CKD if untreated may lead to End Stage Renal Disease (ESRD). Hence, tight glycemic control, and management of hypertension and dyslipidemia is often required to prevent morbidity and mortality. However, this strategy is usually challenging as most of the anti-diabetic therapies need adjustments, modifications or alterations to prevent adverse events and hypoglycemia with CKD. Hence, the aim of the present review is to discuss the up to date existing literature for the management of hyperglycemia with oral agents or insulin among diabetic patients with nephropathy and CKD, while at the same time managing diabetic dyslipidemia and hypertension.
Authors and Affiliations
Athanasia K Papazafiropoulou, Marina S Kardara, Andreas Melidonis
Catalase polymorphism May Influence the Pathogenesis of Diabetes Mellitus
Diabetes is a heterogeneous disease where many factors are involved in its pathogenesis. The genotype frequency of Catalase (CAT) microsatellite polymorphism in patients with Type 1-Diabetes (T1DM) was analysed. 86 T1DM...
Beneficial Effects of a 1-Year Lifestyle Intervention on Metabolic Abnormalities in Overweight and Obese Schoolchildren in Sousse Tunisia: A Pre-Post Quasi- Experimental Study with Control Group
Introduction: The prevalence of obesity in children has increased worldwide during the most recent decades. In this context, we have conducted this study in the purpose to investigate changes in metabolic syndrome in ove...
A Comprehensive Nutriceutical Approach to Metabolic and Vascular Health
A composite nutriceutical containing extracts of Momordica charantia, pine bark extract, hematococcus pluvialis, red yeast rice, the antioxidants alpha-lipoic acid and oxidoreductase ubiquinone Q10, vitamins B9 and B12,...
Autoantibodies in Human Diabetic Depression Inhibit Adult Neural Progenitor Cells In vitro and Induce Depressive-Like Behavior in Rodents
Aim: Diabetic depression increases in association with microvascular complications. We tested a hypothesis that circulating autoantibodies having anti-endothelial and anti-neuronal properties increase in subsets of diabe...
Development of Assessment and Screening Tool to Assist with Prevention and Identification of Charcot Foot in Type 2 Diabetics
The DNP project is intended to improve patient care with the use of an assessment and screening tool and algorithm to aid in early identification of Charcot foot in the type 2 diabetic patient populations. The project in...