STROMAL EXPRESSION OF CD10 IN INVASIVE BREAST CARCINOMA AND ITS CORRELATION WITH KNOWN PROGNOSTIC MARKERS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 71
Abstract
BACKGROUND Breast carcinoma is the most common non-skin malignancy in women. More recently, it has been suggested that extracellular proteinase regulates growth factors and cytokines that might contribute to tumour progression. Since CD10 is a cell surface metalloproteinase which inactivates various biologically active peptides, it might facilitate cancer cell invasion and/or metastasis. MATERIALS AND METHODS 48 cases of Invasive Breast Carcinomas were taken up for the study along with 5 cases of benign tumour as a control group (fibro adenoma and phyllodes). Statistical Analysis: For all statistical data chi-square test was applied using IBM SPSS Statistics 20. RESULTS CD10 was found to be positive in 89% (n=43) cases of which 30.3% (n=13) cases showed weak immunoreactivity whereas strong immunoreactivity was observed in 69.7% (n=30) cases. Stromal CD10 expression correlated with well-established prognostic markers, i.e. higher tumour grade (P<0.001), lymph node metastasis (P=0.003), high mitotic rate (P=0.002), increasing NPI (P=0.003), ER negativity (P=0.032), PR negativity (P=0.041) and HER2/neu positivity (P=0.849). CONCLUSION Stromal CD10 expression in Invasive breast carcinomas is closely correlated with invasion and metastasis and it might play an important role in the pathogenesis.
Authors and Affiliations
Swayamprava Pradhan, Chandan Bajad, Debi Prasad Mishra, Anusuya Dash, Sulata Chowdhary, Samir Kumar Behera, Manoj Kumar Patro, Atanu Kumar Bal
Keywords
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- EP ID EP277888
- DOI 10.18410/jebmh/2017/845
- Views 87
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