Structure and function of mitochondria and its role in male infertility
Journal Title: Central Asian Journal of Medical and Pharmaceutical Sciences Innovation - Year 2022, Vol 2, Issue 6
Abstract
Infertility refers to the inability to conceive after at least 12 months of intercourse without prevention. About half of all infertility factors are due to male factors. Genetic factors are the important factors that contributed to the infertility of men. Genetic factors influencing male infertility can be intra-nuclear or extra-nuclear. A large number of nuclear genes such as protamine genes, aryl hydrocarbon receptors, etc. are involved in male infertility. Deletions and mutations in the genome of mitochondria are one of the most important extra-nuclear factors affecting male infertility. One of the chief features of spermatozoa is its motility, which is essential for the fertilization process. Due to the supply of energy to the sperm by the mitochondria, any defect in it can impair sperm motility and asthenospermia. Mitochondrial genome disorders such as point mutations and genomic deletions, especially the three deletions bp4977, bp7345, and bp7599 may be the main cause of asthenospermia. Identification of mitochondrial molecular defects can be helpful in diagnosing infertility factors, especially asthenospermia. This study aimed to describe the structure and function of mitochondria and its role in the pathophysiology of male infertility.
Authors and Affiliations
Sevinj Maharramova; Sayeddin Atakishizade; Mahbuba Valiyeva; Rovshan Khalilov; Aziz Eftekhari
Keywords
Related Articles
- EP ID EP714399
- DOI 10.22034/CAJMPSI.2022.06.02
- Views 61
- Downloads 0
Association of inflammation with female reproductive system disorders
Inflammation is the body response against infection, injury and illness. It is a significant factor which can affect reproduction processes. Inflammatory state has key roles in physiological reproductive functions in wom...
Aggressive plexiform mandibular ameloblastoma arising from a dentigerous cyst: A case report
Among odontogenic cysts, dentigerous cysts (DC) and among odontogenic tumors, ameloblastoma are the most common. Odontogenic tumors such as ameloblastoma can develop from the cyst lining of dentigerous cyst and also odon...
Potential therapeutic effects of herbal drug resveratrol against cancer
Cancer is a major global problem that faces many therapeutic challenges. Drug resistance can be an important problem in cancer treatment with chemotherapy. The use of plant-based compounds that have anti-cancer propertie...
The cellular and molecular role of exosomes in the pathophysiology of cancer
Exosomes are small extracellular particles enclosed in two lipid layers with the endosomal origin that contain nucleic acids, proteins, and lipids, and are secreted by most cell types. They can transmit their contents fo...
Genetic and epigenetic collaboration in Parkinson’s disease
Parkinson's disease (PD) is a common neurodegenerative syndrome directly related to age development. This pathologic condition presents in many types of forms. Some efforts applied to understand PD development include re...