Studies on Formulation and optimization of Gastro Retentive multiParticulates of Glibenclamide and Metformin hydrochloride for the treatment of Type II Diabetes mellitus using Gelucire: A Review.
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 6
Abstract
In order to increase the bioavailability of poorly soluble drug as well as highly soluble drug, the residence time of the orally administered dosage form in the upper GIT needs to be prolonged. Gelucire are used as carrier for designing low density floating drug delivery system. Glibenclamide is a low dose, poorly soluble drug with possible content uniformity problems and dissolution rate-limited bioavailability while Metformin HCl ranges from 0.5-2.5 gm per day divided in two or three doses taken with meals. Plasma half life is 1.7 –4.5 hrs and absolute bioavailability is 50-60%. There has been contradictory report on the utilization of metformin HCl in single unit gastroretentive dosage form.
Authors and Affiliations
Prashant Upadhyay , Jayant Kumar Pandit , Sukirti Upadhyay , Ashoke Kumar Ghosh
Keywords
Related Articles
- EP ID EP144880
- DOI -
- Views 107
- Downloads 0
PREPARATION AND EVALUATION OF TERNARY MIXING ITRACONAZOLE SOLID DISPERSIONS BY SPRAY DRYING METHOD
The present study aims to experiment the solid dispersion of poorly water soluble drug itraconazole as model drugby spray drying method with the use of PEG/HPMC polymer blends, the influence of polymer compatibilit...
Design, Synthesis and Antiinflammatory Activity of Novel gamma Tocopherol Naproxen Ester Prodrug.
Naproxen is widely used for the treatment of arthritic pain. It can induce gastrointestinal (GI) side effects ranging from stomach irritation to ulceration and bleeding. These complications are believed to be deter...
Evaluation of Anti inflammatory and Analgesic activity of roots of Rubia cordifolia in rats.
The present study was aimed to investigate the analgesic and anti-inflammatory effect of the methanolic extract of root of Rubia cordifolia in rats. Rubia cordifolia (100-300 mg/kg, p.o.) was evaluated for its antiin...
Studies in Formulation Development of Low Dose Content Drug Using Fluid Bed Granulation Technique
To achieve acceptable content uniformity, a granulation process is generally utilized. Fluid bed granulation, wet granulation, dry granulation was used for granulation purpose for formulation of sustained release tablets...
Simultaneous UV Spectrophotometric estimtion of Metoclopramide<br /> hydrochloride and Paracetamol in solid dosage form
A simple, specific, accurate, precise and reproducible method has been developed and validated for the simultaneous estimation of metoclopramide hydrochloride and paracetamol in combined dosage form by UV Spectrophotomet...