Studies on some biochemical effects of aqueous leaf Extract of landolphia owerrience on albino rats
Journal Title: Journal of Research in Biology - Year 2012, Vol 2, Issue 5
Abstract
The effects of aqueous leaf extract (crude) of Landolphia owerrience on some biochemical parameters in adult male and female Albino rats were investigated. Administration of the plant leaf extract was by gavage at a dose level of 20 mg/kg, 30 mg/kg and 40 mg/kg body weight in 0.5 ml saline respectively, daily for 21 days. The concentration of ALT and AST were non-significantly increased as the dose increased. Alkaline phosphatase (ALP) level also increased non-significantly, but not dose dependent. Protein level also significantly increased in a dose dependent fashion. Hemoglobin concentration increased significantly, while lipid peroxidation level decreased non-significantly as the dose increased. The non-significant increase in liver enzyme concentrations in this study showed that the Landolphia owerrience leaf extract may not be toxic to the rat liver, while the low lipid peroxidation levels showed that it may have antioxidant activity
Authors and Affiliations
Friday O Uhegbu, Amadike E Ugbogu, Kingsley C Nwoku
Keywords
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