STUDIES ON THE EFFECT OF ANTIDIABETIC ACTIVITY OF ACHYRANTHES ASPERA L. ON ALLOXAN INDUCED WISTAR RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 9
Abstract
Objective: The present study was designed to investigate the effect of anti-diabetic activity of Achyranthes aspera on alloxan induced wistar rats.Methods: Diabetes was induced by administration of alloxan mono hydrate (150 mg/kg body weight i. p) to albino wistar rats. Diabetic rats were stabilized for four days and from fifth-day aqueous extract of A. aspera were administered at the dose of 250 mg/kg and 500 mg/kg for 45 days. Metformin 1 mg/kg was used as a standard. The effects of A. aspera and standard drug on following parameters was recorded-fasting blood glucose, glycogen, plasma insulin, glycosylated hemoglobin and protein were analyzed in blood samples. Glucose-6-phosphatase, Glucose-6 phosphate dehydrogenase, tissue protein, reduced glutathione, and lipid peroxide were estimated in liver tissues.Results: Our results collectively suggested that administration of aqueous extracts of A. aspera considerably lower the blood glucose level which was comparable to standard anti-diabetic drug metformin (1 mg). Also, the extract shows that considerable increase (p˂0.05) in glucokinase activity when compared to untreated diabetic rats. Lipid peroxidation and reduced glutathione (GSH) level were also studied and the A. aspera aqueous extract and metformin-treated groups shows that the significant (p˂0.05) reduction in lipid peroxide and marked elevation in reduced glutathione levels.Conclusion: Aqueous extract of A. aspera possess anti-diabetic action in alloxan induced diabetic rats.
Authors and Affiliations
K Kamalakkannan, Balakrishnan V
Keywords
Related Articles
- EP ID EP578405
- DOI -
- Views 55
- Downloads 0
SELF-MEDICATION AMONG ADULT POPULATION IN SELANGOR, MALAYSIA
Objective: Self-medication is a common practice and an important health issue worldwide. The aim of this study was to determine the percentage of self-medication practice, patterns of use, self-medication attitudes, and...
MICROBIAL OXIDATION OF FINASTERIDE WITH MACROPHOMINA PHASEOLINA(KUCC 730)
Objectives: New  microbial oxidative derivatives of Finasteride [17β-(N-tert-butylcarbamoyl)-4-aza-5α-androst-1-en-3-one] (1) has been investigated with Macrophomina phaseolina (ATCC730).Methods: Fermented media of  ...
MUTANT P21 PEPTIDES COULD ACT AS AN IMPROVED CYCLIN A INHIBITORS FOR CANCER THERAPY: AN IN SILICO VALIDATION
Objective: The present study delineates the generation of mutant peptide library from a known anticancer peptide, p21 and in silico evaluation for their affinity towards cyclin. A substrate binding groove. Methods: Muta...
SILYMARIN ELICITS PARTIAL PROTECTION AGAINST METHOTREXATE-INDUCED HEPATOTOXICITY IN WISTAR RATS
Objective:Â Methotrexate (MTX) is the gold standard in rheumatoid arthritis treatment; however, its continued use is related to hepatotoxicity. Thus, the aim of the present work is to evaluate the protective role of sil...
EVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF PELLIONIA HEYNEANA WEDD. LEAF ETHANOLIC EXTRACT ON CARBON TETRACHLORIDE INDUCED LIVER DAMAGE IN WISTAR RATSEVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF PELLIONIA HEYNEANA WEDD LEAF E
Objective: The aim of the study was to investigate the antioxidant and hepatoprotective activity of Pellionia heyneana Wedd. leaf ethanolic extract.Methods: The antioxidant potential of the extract was studied by DPPH an...