Study between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubation
Journal Title: International Archives of Integrated Medicine - Year 2018, Vol 5, Issue 8
Abstract
Background: Laryngoscopy and endotracheal intubation, which are a basic and integral part of general anesthesia (GA), are associated with reflex sympathetic stimulation, manifested by tachycardia and hypertension. Aim: The aim was to compare the effect of dexmedetomidine and clonidine on the pressor response among patients undergoing tracheal intubation in elective surgeries under general anesthesia. Materials and methods: A prospective and randomized control study conducted in 80 adult patients of age 18-55 years in ASA I and II were included in this study. Patients were divided into Group D and Group C of 40 patients each. Results: Mean SBP, DBP and MAP in the dexmedetomidine group remained close to the baseline throughout the study period showing a significant difference from clonidine groups following the induction interval. In present study after intubation heart rate, SBP, and DBP was increased in all patients but the increase was more in patients of clonidine group when compared to dexmedetomidine group. There was statistically significant difference in heart rate between the two groups at 1, 3 and 4 min interval after intubation (p value<0.05). No significant changes in peripheral oxygen saturation (SpO2) and cardiac rhythm (ECG) were observed in any patients of both groups. Bradycardia (HR<50/min) was observed in one patient of dexmedetomidine group and two patients in clonidine group, five minutes after intubation. Intraoperative hypotension was observed in one patient of dexmedetomidine group and in two patients of clonidine group. Conclusion: Premedication with dexmedetomidine can safely be recommended for attenuation of provided more stable hemodynamics response to endotracheal intubation.
Authors and Affiliations
K Selvarju, Kondreddi Narayana Prasad, Ajay Kumar Reddy Bobba
Keywords
Related Articles
- EP ID EP415280
- DOI -
- Views 137
- Downloads 0
A study on the effectiveness of Tzanck smear to diagnose the vesiculobullous lesions in comparison with histopathology
Background: Tzanck smear named after Arnault Tzanck (1886-1954), to evaluate Cytopathology as a quick less invasive method for early diagnosis of bullous lesions. Aim: To determine the diagnostic value of Tzanck smear in...
Assessment of major microorganisms involved in diabetic foot infection which delays wound healing
Background: India has the largest diabetic population of 50.8 million that could reach an epidemic proportion by 2030. Diabetic foot infection is one of the dreaded complications of diabetes. Only a few studies that focu...
Assessment of limb salvage in peripheral arterial disease in diabetic foot ulcer: A prospective study
Introduction: The association of peripheral arterial disease in diabetic foot ulcer is an emerging risk factor for accelerated limb amputations. Presence of ischemia delays the wound healing increasing the likelihood of...
Saliva as a diagnostic tool
Salivary diagnostics is an emerging field that has progressed through several important developments in the past decade, including the publication of the human salivary proteome and the infusion of federal funds to integ...
The Impact of Physical Activity on Health Care Student Academic Performance in Riyadh, Saudi Arabia
Background: It is assumed that the students of health care colleges have a greater knowledge about healthy lifestyle and dietary habits when compared to other students. The main goal of this study was to determine the pr...