STUDY OF ALLOIMMUNIZATION AMONG TRANSFUSION DEPENDENT THALASSEMIA PATIENTS
Journal Title: IJAR-Indian Journal of Applied Research - Year 2016, Vol 6, Issue 12
Abstract
Thalassemia is a congenital hemolytic disorder, caused by a partial or complete defect in α or β globin chain synthesis and requires lifelong blood transfusions which may provoke the patient's immune system and produces anti-erythrocyte antibodies (alloantibodies and/or autoantibodies) mainly against ABO, Rhesus, Kell, Duffy etc. Study was carried out on 100 multiply transfused patients with thalassemia. Clinical and transfusion records of all the patients were examined for age of patients, age at initiation of transfusion therapy, total number of blood units transfused, transfusion interval, status of spleen. Alloantibody screening and identification was done using three cell panel (Erythrocyte magnetized technology, Diagast) and 11 cell panel (Diapanel, Bio-rad, Switzerland) w respectively. Out of total 100 patients (2%) developed alloantibodies. 1% belonged to Rh blood group system (Anti-C ), 1% belonged to Kell blood group system.
Authors and Affiliations
DR. SWATI, DR. NEERAJ SHARMA, DR. VIJAY MEHRA, DR. PALWINDER SINGH, DR. ANIL MAHAJAN
Keywords
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