Study of Alteration in Serum Lipids by Enalapril and Ramipril in Albino Rabbits
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 1
Abstract
Hypertension with dislipidemia is becoming a common morbidity, since ACE inhibitors are the first line of antihypertensive drugs so present study was undertaken with the aim to evaluate the possible effects of ACE inhibitor on lipid profile in albino rabbits. Rabbits were divided into 2 groups with 6 in each group. Rabbits of Group I were given Enalapril in dose of 0.50 mg/kg and of group II were given Ramipril in dose of 0.25 mg/kg for a period of 6 weeks. Lipid profile estimation (Serum Total cholesterol, serum HDL, serum LDL, serum Triglycerides and serum VLDL) was done at day 0, 7, 21 and 45 respectively. After analysis Rabbits of group-I (Enalapril) showed 7% decrease in serum cholesterol level at 45th day (P<.05). Serum HDL level increased by 10% and 20% at day 21 & 45 respectively (P<.05). Serum Triglyceride level increases by 8% at day 45 (P<.05). Serum LDL level decreases by 7.8% and 16% at day 21 and 45 respectively.(P<.05 ). There was no significant change in Serum VLDL level. Rabbits of group- II (Ramipril) showed increase in HDL level by 7 % & 12 % at day 21 and 45.(P<.05). Total cholesterol, triglycerides and VLDL levels were not significantaly altered while serum LDL level decreases by 6.8 % at day 45. (P<.05). From our study it was concluded that enalapril had a favourable effect on serum lipid profile by decreasing total cholesterol, increasing serum HDL level. It may increase triglycerides, decrease LDL. Ramipril increase serum HDL and decreases LDL, there is no significant change in cholesterol, TG and VLDL levels.
Authors and Affiliations
Shruti chandra
Keywords
Related Articles
- EP ID EP411138
- DOI -
- Views 129
- Downloads 0
Prescribing trends in the department of orthopedics of a tertiary care teaching hospital
Background Drug utilization studies are necessary to monitor the prescriptions and promote rational drug prescribing among clinicians. Orthopedics department use a wide range of drugs from varied classes to meet the nee...
Evaluation of anti-hyperlipidemic activity of clerodendrum serratum linn on high cholesterol diet induced hyperlipidemia in rats
The main objective of the study was to investigate about the antihyperlipidemic activity of the ethanolic extract from the aerial parts of Clerodendrum serratum Linn (EECS). Qualitative analysis of the extract revealed t...
A comprehensive review on atrial myxoma
An atrial myxoma is a noncancerous tumor in the upper left or right side of the heart. It grows on the wall that separates the two sides of the heart. This wall is called the atrial septum. Atrial myxomas are the most c...
Case study a key tool in Pharm D education
The field of education has a long history of using the case study. The use of case studies has become of increasing interest to those in many areas of education and educational research .Now a days the use of case studie...
To Study the Pharmacological Effect and Beneficial Effect of Eucalyptus Globulus in Different types of Diseases
The plant Eucalyptus globulus, On the basis of study conducted on, it was found that Eucalyptus has storage of active constituent present in its parts; traditionally it is necessary to explore its importance as an excell...