Study of antibacterial activity of combined vaginal pessaries with fluconazole and amaranth oil
Journal Title: Фармацевтичний журнал - Year 2016, Vol 2, Issue 2
Abstract
Today the problem of treatment of vaginal candidosis and creation of effective drugs for the treatment of this disease is actual for modern gynecology and pharmacy. Vaginal candidosis is a variety of fungal infection that is cause by microscopic fungi of Candida, which are conditionally pathogenic. These fungi are the part of the normal human microflora, but in adverse conditions begin to proliferate. Treatment of vaginal candidosis is the etiological and includes applying local antifungal medicines. Ukrainsan pharmaceutical market is represented by drugs of synthetic substances which have considerable side effects and a high level of resistance. Drags based on natural substances are practically absent. The objective of the work was experimental study of antibacterial activity combined vaginal pessaries for the treatment of vaginal candidosis. Models of new extemporaneous pessaries containing fluconazole and amaranth oil were the object of the study. The traditional method «diffusion in the agar» was used in the work. Microbiological studies were conducted on the basis of the Mechnikov Institute under the supervision of candidate of biological sciences Osolodchenko T. P. The diffusion of the drug in agar was carried by the «wells» metod. Statistical processing of results was carried out in accordance with the requirements the State Pharmacopoeia of Ukraine. It is established that pessaries exhibit a pronounced antimicrobic properties and do not concede on the known activity of the drug fluconazole, entitled «Fusys». The proposed composition of the pessaries allows to obtain the drug with significant antimicrobial and antifungal effects and satisfactory physical and chemical characteristics.
Authors and Affiliations
T. G. Yarnykh, Yu. V. Levachkova, V. M. Chushenko, S. M. Pushok
Keywords
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