Study of compatibility of filter materials with solution of meloksmkama for injections
Journal Title: Фармацевтичний журнал - Year 2015, Vol 2, Issue 2
Abstract
One of pharmaceutical design of parenterally solutions times is establishment of influence of filter materials on quality of preparation and choice of optimum filter membranes on the basis of these researches, establishment of optimum size of pores, and sequence of filtration of solution through filters with the different size of pores, that provides the necessary cleaning of injection solution from the mechanical including and microorganisms. The purpose of work was a leadthrough of pharmaceutical development of solution of meloksikama for injections, some aspects of which are lighted up in this article. A research object were «Meloksikam, solution for injection 10 mgs/ml for 1,5 ml in ampoules» and filter membranes, made from a kapron (type of «MIFIL», Byelorussia), nylon (type of «Ultipor N 66», Pall, Germany), poliefirsul'fona (type of «PROPOR PES», Domnik Khanter, England). Control of standards was conducted on methods, to described in DFU and normative document on preparation. Compatibility of solution of meloksikama is well-proven 10 mgs/ml with materials of filters from a kapron (type of «MIFIL», Byelorussia), from a nylon (type of «Ultipor N 66», Pall, Germanу), poliefirsul'fona (type of «PROPOR PES», Domnick Hunter, England). The optimum mode of filtration and assortment of suitable to the use filter materials is chosen taking into account the cross-coupling of components of solution, рН environment and material of filter. For determination of efficiency of filtration, there was a certain index of filtrated of FI (Filtrability Index) and maximal volume of the filtered solution of Vmax. It is set that for achievement of greater efficiency of filtration it is necessary to combine preliminary filtration through membranes with the threshold of detention of 0,6 mkm and steralizing – through membranes with the threshold of detention of 0,2 mkm.
Authors and Affiliations
M. S. Almakaev
Keywords
Related Articles
- EP ID EP583331
- DOI -
- Views 45
- Downloads 0
Directions of optimization of information providing of pharmaceutical prophylaxis care for arterial hypertension
Improvement of informational providing of pharmaceutical prevention care, especially in arterial hypertension, is the main direction for prevention of rational drug use. It was established that only 33% of patients with...
Spectral response аnd electronic structure оf synthetic coumarin derivatives. P a r t IV. Study оf the UV-spectra оf warfarin sodium clathrate
Warfarin is a vitamin K antagonist that was first developed by Wisconsion Alunini Research Foundation in 1947. The use of warfarin in the treatment fоr decrease blood clotting, promotes the emergence of a number of side...
Determination of amino acids content in the flowers of the sorts of chrysanthemum (Chrysanthemum xhortorum Baileyl.)
Amino acids play important roles in the human body. They are the building units of proteins. The aim of our researches was to study amino acids content of the flowers of Chrysanthemum sorts as Finos, Grandeur, Apro, Bel...
Study of antiherpethetical activity of gel altabor
Today herpes infection attracted more and more attention both medical and non-medical circles of society. This is due to the fact that herpes, known since ancient times as a little common and least important disease in r...
Cardiotropic action of combined use of celecoxib and amlodipine in rats sicked on adjuvant arthritis coupled with arterial hypertension
Drug therapy of rheumatoid arthritis combined with arterial hypertension is among actual medical objectives. The complexity of pharmacological treatment of comorbid state is due to not only pathological process severity,...