STUDY OF CROSS-LINKED CROSSCARMELLOSE AS AN ALTERNATIVE SUPERDISINTEGRANT IN FAST DISSOLVING FORMULATION
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 5
Abstract
The present study was aimed towards the formulation and evaluation of Fast dissolution tablets of Aspirin using Cross-linked Crosscarmellose. Fast disintegrating tablets of Aspirin was prepared using three different super disintegrants namely Sodium Starch Glycolate Cross-linked Crosscarmellose, and Non cross-linked Crosscarmellose, and with three concentrations (2%, 3% and 5%) were prepared by direct compression method. The final blend of the drug and excipients were evaluated for powder flow properties, bulk density, tapped density and compressibility index. All the formulations were evaluated for weight variation, thickness, disintegration time, hardness, friability, wetting time and water absorption ratio. Formulation F1 showed the lowest disintegration time. In vitro dissolution studies revealed that formulation F1 showed 99.96 % percent drug release at the end of 30 minutes. These results revealed that the formulation F6 containing. Cross-linked Crosscarmellose (5%) as super disintegrant was better one which satisfied all the criteria as a Fast Disintegrating tablets.
Authors and Affiliations
Dada D. Kodalkar
Keywords
Related Articles
- EP ID EP627019
- DOI -
- Views 161
- Downloads 0
A REVIEW ON THE PREPARATION OF VINEGAR FROM FRUIT PEELS.
Vinegar is the product obtained exclusively through biotechnological processes such as double fermentation, alcoholic acetic fermentation of the liquid. There are various types of vinegars obtained from various sources s...
REVIEW ARTICLE
Pulsatile drug delivery systems are gaining a lot of interest as they deliver the drug at the site of action, at the right time and in the right amount, as per the pathophysiological needs of the diseases, resulting in i...
‘COLD’ CURTAILS THE PAIN IN ENDODONTICS?
In general, pain is defined as an “unpleasant sensory & emotional experience associated with actual or potential tissue damage”. Tooth pain is one of the most dreaded experiences cited by most people and a significant nu...
MONOCAPRYLIN AND DICAPRYLIN PRODUCTION BY IMMOBILIZED LIPASE USING BATCH AND FED-BATCH OPERATING MODES
Esterification of glycerol (G) with caprylic acid (CA) catalyzed by immobilized lipases (Lipozyme IM and Palatase® - 1X2-400) was carried out in a 125 mL bench reactor operated at batch and fed-batch mode. Tests were pla...
ANALYTICAL STUDY OVER PIPPALYADI VATI – AN APPETIZER
Deepana and pachana Karma is indicated as Purvakarma before administration of Snehapana for Shodhana in conditions such as Mamsala (Upachita Mamsa), Medura (Medasvina), Bhurishleshma, and Vishamagni because they are Sneh...