Study of Dermal Vascular Changes in Inflammatory Skin Diseases
Journal Title: Saudi Journal of Pathology and Microbiology - Year 2018, Vol 3, Issue 3
Abstract
Abstract:The skin is the largest organ in the body. A multitude of diseases are linked to an insufficient or overactive dermal vasculature. Vessels change their phenotype,i.e. vascular remodelling in inflammatory conditions. The aim of this study was to analyse the dermal vascular alterations in various inflammatory skin diseases & to assess their utility in establishing the differential diagnosis. A unicenter study of 55 (fifty five) skin biopsies received from patients of various non tumorous common inflammatory skin diseases such as, psoriasis, lichen planus, erythema multiform, blistering (bullous) lesions and 10 control samples were studied. Morphometric analysis was performed on CD 34 immunostained sections using image analysis software (Leica Q Win V3 software analysis system). Mean vascular density (MVD) and mean vascular calibre (MVC) was calculated. The MVD was maximum in psoriasis, followed by lichen planus, bullous lesions and erythema multiform. MVD in psoriasis was significantly higher than the controls. MVC was highest in psoriasis followed by erythema multiform, lichen planus and bullous lesions. The MVC in psoriasis, erythema multiform, lichen planus, bullous lesions were significantly higher than the controls. Elongated, tortuous blood vessels were more prominent in psoriasis. The endothelial changes noted were swelling in the form of nuclear hypertrophy, increased cytoplasm and endothelial gaps. Angiogenesis was increased in inflammatory skin diseases and it was highest in psoriasis. Therefore, therapeutic intervention at the level of vasoproliferation may prove to be useful. Keywords: Psoriasis, Lichen Planus, bullous lesions, Mean vascular density, Mean vascular calibre.
Authors and Affiliations
Charusheela R Gore, Pradnya Shende, Sourabh P Paranjape, Padmakar R Bardapurkar, Shirish S Chandanwale, Namrata Patro
Keywords
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