Study of Diabetic Retinopathy In Terms Of Fundus Finding, OCT Changes and FFA Finding & Correlation with Biochemical Parameters Presenting To Eye OPD
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Background: Diabetic Retinopathy (DR) is most important cause of legal blindness between 20-70yr age group. Periodic glycosylated haemoglobin (HbA1c) measurements can reflect the long-term control of hyperglycaemia. Intensive glycemic control had been proved to be effective in decreasing incidence rate of development and progression of DR in type 1 and type 2 DM. Hyperlipidaemia (LDL, TG) causes endothelial dysfunction due to reduced bioavailability of nitric oxide and breakdown of blood retinal barrier leading to exudation of serum lipids and lipoproteins which results in DR changes and diabetic macular odema (DME) formation. Methods: A prospective study was carried on 205 eyes of 110 cases of DR Results: Study showed the diagnostic potential and efficacy of OCT and FFA over ophthalmoscopic fundus examination in detection of DR. 95/205(46%) eyes of DME & DR showed increased in severity with abnormal biochemical parameters. Mean HbA1C for Severe NPDR and PDR is >8.4. Lipid profile (TG, LDL) also correlated with more DME and increase in severity of stage with level >150 of TG and >130 of LDL Level, however, no significant correlation was found between LFT, RFT and stages of DR. Conclusion: OCT is rapid non invasive technique provides valuable information about retinal thickness and also helps in monitoring the response to treatment in DME (Laser or AntiVEGF). FFA is essential for assessment of foveal perfusion state and helps in diagnosis of Macular ischemia in eyes with unexplained vision loss. We conclude that decreasing in HbA1c values and control of lipid alterations is required at least to postpone or prevent loss of vision from retinopathy.
Authors and Affiliations
Dr. Sanjeev K. Nainiwal, Dr. Neelam Meena
Keywords
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- EP ID EP467650
- DOI 10.9790/0853-1802120115.
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