Study of Dyslipidemia in Patients with Systemic Lupus Erythematosus and its Correlation to Disease Activity

Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 73, Issue 5

Abstract

Background: Cardiovascular events and accelerated atherosclerosis in patients with active systemic lupus erythematosus results in significant increased morbidity and mortality. The non-traditional risk factors induce alteration in lipoprotein metabolism and the constant inflammatory and immune activity can lead to accelerated atherosclerosis. Aim: To assess prevalence of dyslipidemia in systemic lupus erythematosus patients and to study the relation of dyslipidemia to disease activity. Patients and methods: The presented study included 60 SLE adult patients (56 females and 4 males) and they were classified according to disease activity into two groups: Active Lupus: Included 30 lupus patients. Inactive Lupus: Included 30 lupus patients. 20 healthy subjects with matched age, sex and BMI were included as healthy controls. Methods: Patients underwent clinical assessment. Total cholesterol, (LDL, HDL) and triglyceride were measured. Results: Cholesterol, LDL, and TG levels were elevated in the active group compared to that in the inactive group and healthy controls. This elevation was significant (P< 0.001). But HDL level decreased in the active group compared to the inactive and healthy controls groups. The decrease of HDL was the active group is significant (P< 0.001). Conclusion: The elevated levels of Total cholesterol, LDL, and TG and decreased level of HDL in SLE patients are considered an independent risk factor for cardiovascular disease. The dyslipidemia and inflammatory process predispose to premature atherosclerosis and disease activity contribute to dyslipidemia and hence cardiovascular risk associated with SLE.

Authors and Affiliations

Keywords

Related Articles

Awareness and Attitude towards Epilepsy among Saudi Arabia

<span>Background: </span><span>Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures and by the neurobiological, cognitive, psychological, and social consequences...

Comparative Study of Positron Emission Tomography /Computed Tomography and Whole-Body Bone Scanning for Detecting Bone Metastasis in Patients with Breast Cancer

Objective: the aim of this study was to compare the role of PET/CT & bone scintigraphy in detection of bone metastasis in patients with breast cancer. Patients and methods: The present study included 30 patients with bre...

Evaluation of the Risk Factors and Emergency Management Plan of Status Asthmatics in Children: A Simple Literature Review

<span>Background: </span><span>Significant research papers were published to assess different risk factors associated with development of status asthmaticus (SA) in children and prevention. Understanding the different ri...

Serum Copper and Zinc levels in Vitiligo Patients

Background: vitiligo is a common, acquired, discoloration of the skin, characterized by well circumscribed, ivory or chalky white macules and patches. Researchers suggested that vitiligo may arise from autoimmune (AI), g...

Evaluation of the Association of Bariatric Surgery with Development of Cholelithiasis

<span>Background: </span><span>Significant research papers have been published to assess the relation between rapid weight loss and the development of cholelithiasis, and the risk factors behind it. Assessment of choleli...

Download PDF file
  • EP ID EP611442
  • DOI -
  • Views 128
  • Downloads 0

How To Cite

(2018). Study of Dyslipidemia in Patients with Systemic Lupus Erythematosus and its Correlation to Disease Activity. The Egyptian Journal of Hospital Medicine, 73(5), -. https://europub.co.uk./articles/-A-611442