Study of Early Renal Dysfunction in Type 2 Diabetics with Special Reference to Serum Cystatin C Levels and Microalbuminuria
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 10
Abstract
India is becoming Diabetic capital of the world with a parallel increase in long term complications associated with Diabetes. This study was done to evaluate Cystatin C as a marker for detecting early renal dysfunction in Diabetic Nephropathy. Serum Cystatin C and Urine Albumin levels were measured in 100 type 2 Diabetics alongwith other parameters like FBS, HbA1c, Serum Urea and Creatinine, blood pressure and lipid profile. e GFR was calculated using CKD-EPI equations.Mean Cystatin C concentrations showed stepwise statistically significant increases as eGFR reduces and also increases with increasing level of albuminuria(p<0.001). Among normoalbuminuric patients(n =46), 17.4 % patients were having increased Serum Cystatin C as compared to 4.3% patients having increased Serum Creatinine( p<0.001).In ROC analysis, area under curve of Serum Cystatin C is 0.758 (p<0.001) which signify that Serum Cystatin can be a fair predictor of Nephropathy. Glycemic control, blood pressure and dyslipidemia were directly related with albuminuria and eGFR. This study supports the use of Cystatin C for detecting early renal dysfunction as compared to conventional markers.
Authors and Affiliations
Anurag Chaurasia, Saloni Sinha, Manoj Indurkar, Rakesh Patel
Keywords
Related Articles
- EP ID EP478911
- DOI -
- Views 45
- Downloads 0
Study of Autonomic Manifestations in Patients with Diabetes Mellitus Attending a Tertiary Care Hospital in Coastal City of South India
Abstract: Diabetes Mellitus, in all its forms has emerged as a major health burden worldwide including India. Autonomic neuropathy is one which is often a disabling complication of Diabetes Mellitus. 50 patients admitted...
Role of-463 G/A Genetic Polymorphism & Myeloperoxidase Activity in Prediction of Cardiovascular Disease
Abstract: Myeloperoxidase (MPO), a hemoprotein abundantly expressed by polymorphonuclear neutrophills (PMNs) secreted during activation, possess potent proinflammatory properties and contribute directly to tissue injury....
Utilization of Emergency Services of a Tertiary Care Hospital: Work Load, Time Trends, Common Diseases, Length of Stay and Admission Pattern
Abstract: The emergency department is a core clinical unit and busiest area of a hospital. The experience of patients attending emergency department significantly influences patient satisfaction and the public image of t...
Can the sudarshan kriya yoga have any effect on sympathetic function test in pre-hypertensive patient?
Sudarshan Kriyas is known to eliminate stress, fatigue and negative emotions such as anger, frustration and depression, leaving you calm yet energized, focused yet relaxed. This study evaluated the effects of sudarshan K...
Comparison of Surgical Outcome of Prone PCNL Vs Supine PCNL
Abstract: Percutaneous nephrolithotomy (PCNL) in the prone position has been established approach, but it is associated with various anesthetic and logistic difficulties. In our study we aimed at comparing the surgical o...