Study of efficacy and safety of second line art regimen in HIV/AIDS patients in a tertiary care centre
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 4
Abstract
Background The advent of HAART has decreased the progression to AIDS and AIDS related mortality and prolonged the survival .On the other hand, advances in the antiretroviral therapy have increased life span of HIV positive patients significantly. However, increased duration of antiretroviral treatment in such treatment-experienced patients is associated with the problems of adverse drug reactions (ADRs), drug interactions and emergence of drug resistant strains of HIV. Aims and objectives To assess the therapeutic response of second line ART regimen consisting of tenofovir + lamivudine + atazanavir and ritonavir by CD4 count and plasma viral load in HIV patients. Methods This was a longitudinal, prospective, observational study carried out in HIV positive patients attending ART centre, government general hospital, Vijayawada. Patients receiving first-line ARV drugs for at least six months were evaluated clinically, immunologically (CD4 count) and virologically (plasma viral load) for failure and started on second-line ART from November 2011 to November 2012 were included in the study. Results Out of 100 patients, 52 patients developed ADRs. In this 52, 34 patients had CD4+ count <250 cells/cu.mm and the remaining 18patients had CD4+ count >250 cells/cu.mm. The observed difference was statistically significant (p<0.0001). The plasma viral load after six months of therapy were decreased compared to the initial mean values. Conclusion The ADRs were most common in those patients whose CD4+ count is <250 cells/cu.mm. Early treatment outcome with second line ART in terms of immunological improvement and viral suppression was good in treatment experienced patients. Though atazanavir containing regimen is more efficacious but produces more serious adverse effects.
Authors and Affiliations
Savithri Desai
Keywords
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