Study of Fasting and Postprandial Lipid Abnormality in Type 2 Diabetes Mellitus and Its Correlation with Vascular Complications of Diabetes
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 5, Issue 11
Abstract
Introduction: High cardiovascular mortality which is associated with Type 2 diabetes mellitus (T2DM) is due to a prolonged, exaggerated postprandial (PP) state. The abnormal lipid profile in the PP state is more significant than that in the fasting state in causing atherosclerotic complications in T2DM. Aims and Objectives: The objective of this study is to find fasting and postprandial lipid abnormality in T2DM patients and its correlation with vascular complications of T2DM. Material and Methods: Fasting and PP lipids were measured in 150 T2DM patients. On the basis of normal and abnormal fasting lipid profiles, diabetic patients were divided into controls and cases, respectively, and evaluation for various complications was done and statistically analyzed. Results: The result of this study showed a significant elevation in mean values of fasting blood glucose, serum cholesterol (SCH), low-density lipoproteins (LDL), very LDL, and triglycerides in the PP state in cases as compared to controls (P < 0.05). Waist-to-hip ratio in cases (mean 0.96 ± 0.02) was significantly higher (P = 0.00) as compared to that in controls (mean 0.93 ± 0.03). Microvascular complications such as retinopathy, nephropathy, and neuropathy were found significantly more in cases (46%, 55%, and 63%, respectively) as compared to controls (P < 0.05). Most common macrovascular complication observed in cases were IHD (24.6%) and least common were Peripheral Vascular Disease (10.6%). while there was no significant difference (P>0.05) found in occurrence of macrovascular complications in between cases and controls. Conclusion: Since we are in the PP phase for most of the day, it is important to estimate the PP lipid profile along with fasting lipid profile, as atherosclerosis is a PP phenomenon with respect to lipids, Thus correction in early phase can prevent complications. So in routine practice PP lipid profile along with fasting is warranted.
Authors and Affiliations
P Punekar, J K Jatav, D S Bantewad
Keywords
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