Study of Fine Needle Aspiration Cytology of Thyroid Lesions by Morphometry
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 7
Abstract
Fine Needle Aspiration Cytology (FNAC) is used as the screening procedure for thyroid nodules. FNAC utilizes size of cell and nuclei and shape of cells as a criterion for diagnosis and helps in the diagnosis of malignant lesions. Computer-assisted image morphometry is a tool for measuring cytological variables which characterise the size and shape of nuclei. This could be used along with FNAC for diagnosis of thyroid lesions The main objectives of this study were:(a) to evaluate nuclear morphometric features i.e. major axis(MAJX), minor axis(MINX), nuclear area(NA), nuclear perimeter(NP), nuclear aspect ratio(ASPR) and nuclear roundness(NR) in FNAC of thyroid lesions and (b) to compare these parameters in various groups and to assess their diagnostic utility in thyroid lesions. We evaluated nuclear morphometric parameters using digital imageanalyzing software in 88 thyroid lesions in FNAC smears. There were: a) 15 cases of papillary Carcinoma, b) 15 cases of lymphocytic thyroiditis, c) 41 cases of colloid goiter and d) 17 cases of follicular lesions. Statistical evaluation using the analysis of variance (ANOVA) with turkey HSD test was carried out. ANOVA test showed that size related nuclear parameters: MeanMAJX, MINX, NA and NP with their variability were significantly differentfor the four groups. These parameters were significantly greater (p<0.05) in cases of papillary carcinoma than other groups unlike shape related parameters, ASPR and NR. Size related parameters in lymphocytic thyroiditiswas significantly greater than colloid goiter. Morphometric parameters can be gainfully exploited in the diagnosis of thyroid lesions
Authors and Affiliations
Col Dr. Jasvinder Kaur Bhatia, Dr. D Boruah, Dr. R Manglem
Keywords
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