Study of High Sensitive-CRP and Cardiac Marker Enzymes in Acute Coronary Syndrome 

Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2015, Vol 4, Issue 2

Abstract

Background: Inflammation has been proposed as a contributor to different stages in the pathogenesis of Coronary Heart Disease (CHD). High sensitive C-Reactive Protein (hs-CRP), an acute-phase plasma protein synthesized by the liver, is the most extensively studied systemic marker of inflammation. Elevated hsCRP concentrations early in Acute Coronary Syndrome (ACS), prior to the tissue necrosis, may be a surrogate marker for cardiovascular co-morbidities. The cardiac marker enzymes Creatine Kinase myocardial bound (CK-MB), Aspartate Aminotransferase (AST) and lactate dehydrogenase (LDH) have been known to be increased in coronary artery diseases. Objective: The aim of the study was to measure hs-CRP levels and other cardiac marker enzymes in ACS patients and to compare the levels of hs-CRP with other cardiac marker enzymes between ST Elevation Myocardial Infarction (STEMI) and Non-ST Elevation Myocardial Infarction (NSTEMI) patients. Material and Methods: The study group consisted of 207 consecutive patients admitted to Sri Siddhartha Medical College Hospital within the first 6 hours from the onset of chest pain. Patients were diagnosed as Unstable Angina (UA), (n=84); STEMI (n=63) and NSTEMI (n=60). ACS patients were compared with 211 healthy age and sex matched controls. Hs-CRP, CK-MB, AST and LDH levels were measured by standard methods in both groups at baseline and forcases at 36-48 hours i.e. Peak levels. Results: ACS patients had significantly (p<0.05) higher levels of hs-CRP, CKMB, AST and LDH in comparison to controls at baseline. Hs-CRP, CK-MB, AST and LDH levels were significantly higher in STEMI patients compared to NSTEMI patients (p<0.05) at baseline. There was a significant difference regarding peak hs-CRP levels between the two groups, as STEMI patients had significantly higher peak hs-CRP levels compared to NSTEMI patients (p<0.05). Conclusion: STEMI patients have significantly higher peak hsCRP levels compared to NSTEMI patients. These data suggest that inflammatory processes play an independent role in the pathogenesis of myocardial infarction. Thus, Hs-CRP assessment may assist in risk stratification after myocardial infarction 

Authors and Affiliations

Srikrishna R , Ramesh S. T , Girishbabu R. J

Keywords

Related Articles

Assessment of Causes and Clinical Symptoms of Menorrhagia and Its Co-relation with BMI in Western Nepalese Women - An Observational Study

Background: Menorrhagia is defined subjectively as heavy menses lasting for more than 7 days or objectively as a mean menstrual blood loss of >80 ml during three consecutive menses. It can occur due to organic causes lik...

Cytological Diagnosis of Primary Cutaneous Nocardiosis in a Known Case of Lepromatous Leprosy, Syphilis and HIV 

Nocardiosis is an acute, subacute or chronic bacterial infection caused by a group of aerobic, gram positive and weakly acid fast species of genus Nocardia. Primary Cutaneous Nocardiosis (PCN) is relatively uncommon...

An Interesting Journey of an Endobronchial Foreign Body - A Case Report 

Reported incidence of spontaneous expulsion of chronically impacted foreign body from a segmental bronchiole is very less. We report a rare and fascinating journey of an iron nail which was accidentally inhaled two y...

Drug-Drug Interactions among Elderly Patients at Hospital Discharge: A Cross-Sectional Descriptive Study

Background: The presence of multiple comorbidities makes prescription of multiple drugs essential in the elderly. Thisis attended with an increased risk of potential drug-drug interactions (DDIs). Aim and objectives: To...

Herlyn-Werner-Wunderlich Syndrome with Degenerating Fibroid–Uncommon Presentation of a Rare Anomaly

Herlyn-Werner-Wunderlich Syndrome (HWWS) is a rare congenital anomaly of Mullerian and mesonephric ducts characterized by uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis. It commonly presents a...

Download PDF file
  • EP ID EP163485
  • DOI -
  • Views 99
  • Downloads 0

How To Cite

Srikrishna R, Ramesh S. T, Girishbabu R. J (2015). Study of High Sensitive-CRP and Cardiac Marker Enzymes in Acute Coronary Syndrome . Journal of Krishna Institute of Medical Sciences University, 4(2), 107-113. https://europub.co.uk./articles/-A-163485