Study of Hyponatremia in Acute ST-Elevation Myocardial Infarction and Its Prognostic Importance
Journal Title: Journal of Medical Research and Practice - Year 2017, Vol 6, Issue 2
Abstract
Background In spite of lots of advancements in methods for diagnosis and treatment, Coronary artery disease is still the most important cause of death in both developed and developing countries. Dyselectrolytemia-like hyponatremia is common in patients with heart failure and in acute myocardial infarction (AMI). The study was conducted to observe the incidence of hyponatremia and its importance in predicting short-term major adverse cardiac events (MACE) in acute ST elevation MI (STEMI). Aim The aim of this study was to examine whether the presence hyponatremia (serum sodium < 135 mEq/L) can predict MACE in patients with acute STEMI. Methods A total of 100 patients (80 men and 20 women) with acute STEMI were studied prospectively. The main outcome measures of the study were based on a comparison of in-hospital mortality and major non-fatal in-hospital events (arrhythmia, cardiogenic shock, and heart failure) between hyponatremic and normonatremic patients. Result A substantial proportion (29%) of patients who presented with acute STEMI were either hyponatremic on admission or developed hyponatremia within 72 h of admission. Out of 6 patients in hyponatremic group, 3 patients died, 5 developed heart failure and 2 had sustained ventricular tachycardia. Patients, who developed MACE also correlated well with the severity of hyponatremia. In multivariate logistic regression analysis, hyponatremia remained a significant independent predictor of 7-day MACE. Conclusion Hyponatremia is a significant independent predictor of in-hospital mortality and morbidity in patients with acute STEMI.
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Sijoy kurian
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